Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis

Fernando M. Reis, Anna M. Di Blasio, Pasquale Florio, Guido Ambrosini, Carla Di Loreto, Felice Petraglia

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; immunostaining of α and βA subunits in ovarian endometrioma; α and βA gene expression in cultured endometriotic cells compared with normal endometrium. Result(s): Inhibin A and activin A concentrations in the cystic fluid were slightly higher than in peritoneal fluid and significantly higher than in serum (P

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalFertility and Sterility
Volume75
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Activin
  • Endometriosis
  • Inhibin
  • Ovarian cyst
  • Ovary

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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