Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection

G. Pantaleo, H. Soudeyns, J. F. Demarest, M. Vaccarezza, C. Graziosi, S. Paolucci, M. B. Daucher, O. J. Cohen, F. Denis, W. E. Biddison, R. P. Sekaly, A. S. Fauci

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analyzed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance or clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.

Original languageEnglish
Pages (from-to)9848-9853
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number18
DOIs
Publication statusPublished - 1997

Fingerprint

HIV Infections
Clone Cells
HIV
T-Lymphocytes
Cytotoxic T-Lymphocytes
T-Cell Antigen Receptor
Viruses
Viremia
Infection
Cellular Immunity
Epitopes
Down-Regulation
Mutation

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. / Pantaleo, G.; Soudeyns, H.; Demarest, J. F.; Vaccarezza, M.; Graziosi, C.; Paolucci, S.; Daucher, M. B.; Cohen, O. J.; Denis, F.; Biddison, W. E.; Sekaly, R. P.; Fauci, A. S.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 18, 1997, p. 9848-9853.

Research output: Contribution to journalArticle

Pantaleo, G, Soudeyns, H, Demarest, JF, Vaccarezza, M, Graziosi, C, Paolucci, S, Daucher, MB, Cohen, OJ, Denis, F, Biddison, WE, Sekaly, RP & Fauci, AS 1997, 'Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection', Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 18, pp. 9848-9853. https://doi.org/10.1073/pnas.94.18.9848
Pantaleo, G. ; Soudeyns, H. ; Demarest, J. F. ; Vaccarezza, M. ; Graziosi, C. ; Paolucci, S. ; Daucher, M. B. ; Cohen, O. J. ; Denis, F. ; Biddison, W. E. ; Sekaly, R. P. ; Fauci, A. S. / Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. In: Proceedings of the National Academy of Sciences of the United States of America. 1997 ; Vol. 94, No. 18. pp. 9848-9853.
@article{925283fe5e1945c8aef968a84da3ef2e,
title = "Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection",
abstract = "Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analyzed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance or clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.",
author = "G. Pantaleo and H. Soudeyns and Demarest, {J. F.} and M. Vaccarezza and C. Graziosi and S. Paolucci and Daucher, {M. B.} and Cohen, {O. J.} and F. Denis and Biddison, {W. E.} and Sekaly, {R. P.} and Fauci, {A. S.}",
year = "1997",
doi = "10.1073/pnas.94.18.9848",
language = "English",
volume = "94",
pages = "9848--9853",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "18",

}

TY - JOUR

T1 - Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection

AU - Pantaleo, G.

AU - Soudeyns, H.

AU - Demarest, J. F.

AU - Vaccarezza, M.

AU - Graziosi, C.

AU - Paolucci, S.

AU - Daucher, M. B.

AU - Cohen, O. J.

AU - Denis, F.

AU - Biddison, W. E.

AU - Sekaly, R. P.

AU - Fauci, A. S.

PY - 1997

Y1 - 1997

N2 - Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analyzed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance or clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.

AB - Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analyzed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance or clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.

UR - http://www.scopus.com/inward/record.url?scp=0030928759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030928759&partnerID=8YFLogxK

U2 - 10.1073/pnas.94.18.9848

DO - 10.1073/pnas.94.18.9848

M3 - Article

C2 - 9275214

AN - SCOPUS:0030928759

VL - 94

SP - 9848

EP - 9853

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 18

ER -