Evidence for serotonin-S2 receptor involvement in analgesia in humans

Giorgio Sandrini, Enrico Alfonsi, Carlo De Rysky, Stefano Marini, Fabio Facchinetti, G. Nappi

Research output: Contribution to journalArticlepeer-review


The possible analgesic activity of ritanserin (a new very selective and potent serotonin-S2 antagonist) was studied (double-blind) in humans. A significant increase in nociceptive flexion reflex threshold and subjective pain threshold was observed after five days of treatment, while treatment with placebo did not induce any change. The effects of ritanserin were not reversed by either naloxone or saline (double-blind) administration. Our data suggest a possible role of serotonin-S2 receptors in analgesia.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
Publication statusPublished - Nov 4 1986


  • (Human)
  • Analgesia
  • Naloxone
  • Nociceptive flexion reflexes
  • Serotonin-S receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology


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