TY - JOUR
T1 - Evidence for the presence of immunoreactive POMC-derived peptides and cytokines in the thymus of the goldfish (Carassius c. auratus)
AU - Ottaviani, E.
AU - Franchini, A.
AU - Franceschi, C.
PY - 1995/8
Y1 - 1995/8
N2 - The presence of immunoreactive pro-opiomelanocortin (POMC)-derived peptides (adrenocorticotropin hormone, β-endorphin, α-melanocyte-stimulating hormone) and of cytokine-like molecules [interleukin (IL)-1α, IL-1β, IL-2, IL-6, tumour necrosis factor-α] was demonstrated in periodic acid-Schiff-positive epithelial cells in the thymus of the goldfish (Carassius c. auratus) using immunocytochemical procedures. POMC-derived peptide- and cytokine-like molecules were localized in the same cell type. Lymphocytes were negative for all the above mentioned molecules. Despite the smaller number of cells positive for neuropeptide- and cytokine-like molecules, our findings suggest that immune-neuroendocrine interactions are likely to occur in the thymus of goldfish.
AB - The presence of immunoreactive pro-opiomelanocortin (POMC)-derived peptides (adrenocorticotropin hormone, β-endorphin, α-melanocyte-stimulating hormone) and of cytokine-like molecules [interleukin (IL)-1α, IL-1β, IL-2, IL-6, tumour necrosis factor-α] was demonstrated in periodic acid-Schiff-positive epithelial cells in the thymus of the goldfish (Carassius c. auratus) using immunocytochemical procedures. POMC-derived peptide- and cytokine-like molecules were localized in the same cell type. Lymphocytes were negative for all the above mentioned molecules. Despite the smaller number of cells positive for neuropeptide- and cytokine-like molecules, our findings suggest that immune-neuroendocrine interactions are likely to occur in the thymus of goldfish.
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U2 - 10.1007/BF00173096
DO - 10.1007/BF00173096
M3 - Article
C2 - 8550379
VL - 27
SP - 597
EP - 601
JO - Histochemical Journal
JF - Histochemical Journal
SN - 0018-2214
IS - 8
ER -