Evidence for the presence of immunoreactive POMC-derived peptides and cytokines in the thymus of the goldfish (Carassius c. auratus)

E. Ottaviani, A. Franchini, C. Franceschi

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The presence of immunoreactive pro-opiomelanocortin (POMC)-derived peptides (adrenocorticotropin hormone, β-endorphin, α-melanocyte-stimulating hormone) and of cytokine-like molecules [interleukin (IL)-1α, IL-1β, IL-2, IL-6, tumour necrosis factor-α] was demonstrated in periodic acid-Schiff-positive epithelial cells in the thymus of the goldfish (Carassius c. auratus) using immunocytochemical procedures. POMC-derived peptide- and cytokine-like molecules were localized in the same cell type. Lymphocytes were negative for all the above mentioned molecules. Despite the smaller number of cells positive for neuropeptide- and cytokine-like molecules, our findings suggest that immune-neuroendocrine interactions are likely to occur in the thymus of goldfish.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalHistochemical Journal
Issue number8
Publication statusPublished - Aug 1995


ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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