Evidence for the single origin of hb g-san jose in sicily

L. Cremonesi, M. Travi, S. Li Volti, R. Testa, G. Schiliro, M. Ferrari

Research output: Contribution to journalArticle

Abstract

Hb G-San Jose [α2β27(A4)Glu→Gly] was detected in four families and three unrelated individuals from Eastern Sicily. Polymorphic restriction sites within the βglobin gene cluster bearing the mutation were characterized. A complete association of βG-San Jose alleles with Mediterranean haplotype IV was found in the families examined and the same haplotype was also present in the unrelated individuals. These findings support the hypothesis of an unicentric origin of the βG-San Jose mutation which may have arisen in Eastern Sicily.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalHemoglobin
Volume13
Issue number6
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical
  • Biochemistry

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    Cremonesi, L., Travi, M., Volti, S. L., Testa, R., Schiliro, G., & Ferrari, M. (1989). Evidence for the single origin of hb g-san jose in sicily. Hemoglobin, 13(6), 579-584. https://doi.org/10.3109/03630268908993108