Evidence of a selective nociceptive impairment in systemic sclerosis

Gianluigi Bajocchi, Rossana Terlizzi, Stefano Zanigni, Giorgio Barletta, Daniela Grimaldi, Giulia Pierangeli, Pietro Cortelli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. To test for the autonomic neuropathy in systemic sclerosis (SSc) using cardiovascular reflex evaluation including the "cold face test", which elicits forehead cold receptors (C-fibres). These tests examine the induced bradycardia-hypertensive response and the integrity of nociceptive afferent and parasympathetic-sympathetic efferent pathways. Methods. Twelve SSc patients were studied; including 5 with the limited cutaneous (lcSSc) involvement, and 7 with diffuse cutaneous involvement (dcSSc). All patients were matched with healthy controls. We performed cardiovascular autonomic tests (tilt-test, Valsalva manoeuver, deep breathing, sustained handgrip and cold face) with continuous monitoring of beat-to-beat blood pressure (BP) and heart rate (HR). Baroreceptor sensitivity index (BRSI) and power spectral analysis (PSA) of heart rate variability (HRV) were also evaluated. Results. SSc patients showed a statistically significant higher HR at rest (p

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume27
Issue number3 SUPPL. 54
Publication statusPublished - 2009

Fingerprint

Systemic Scleroderma
Heart Rate
Efferent Pathways
Valsalva Maneuver
Skin
Pressoreceptors
Forehead
Bradycardia
Reflex
Respiration
Blood Pressure

Keywords

  • Cardiovascular autonomic dysfunction
  • Heart rate variability
  • Raynaud's phenomenon
  • Small fibres neuropathy
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Evidence of a selective nociceptive impairment in systemic sclerosis. / Bajocchi, Gianluigi; Terlizzi, Rossana; Zanigni, Stefano; Barletta, Giorgio; Grimaldi, Daniela; Pierangeli, Giulia; Cortelli, Pietro.

In: Clinical and Experimental Rheumatology, Vol. 27, No. 3 SUPPL. 54, 2009.

Research output: Contribution to journalArticle

Bajocchi, Gianluigi ; Terlizzi, Rossana ; Zanigni, Stefano ; Barletta, Giorgio ; Grimaldi, Daniela ; Pierangeli, Giulia ; Cortelli, Pietro. / Evidence of a selective nociceptive impairment in systemic sclerosis. In: Clinical and Experimental Rheumatology. 2009 ; Vol. 27, No. 3 SUPPL. 54.
@article{165cc6b8049a4f6ca1769504404ce073,
title = "Evidence of a selective nociceptive impairment in systemic sclerosis",
abstract = "Objective. To test for the autonomic neuropathy in systemic sclerosis (SSc) using cardiovascular reflex evaluation including the {"}cold face test{"}, which elicits forehead cold receptors (C-fibres). These tests examine the induced bradycardia-hypertensive response and the integrity of nociceptive afferent and parasympathetic-sympathetic efferent pathways. Methods. Twelve SSc patients were studied; including 5 with the limited cutaneous (lcSSc) involvement, and 7 with diffuse cutaneous involvement (dcSSc). All patients were matched with healthy controls. We performed cardiovascular autonomic tests (tilt-test, Valsalva manoeuver, deep breathing, sustained handgrip and cold face) with continuous monitoring of beat-to-beat blood pressure (BP) and heart rate (HR). Baroreceptor sensitivity index (BRSI) and power spectral analysis (PSA) of heart rate variability (HRV) were also evaluated. Results. SSc patients showed a statistically significant higher HR at rest (p",
keywords = "Cardiovascular autonomic dysfunction, Heart rate variability, Raynaud's phenomenon, Small fibres neuropathy, Systemic sclerosis",
author = "Gianluigi Bajocchi and Rossana Terlizzi and Stefano Zanigni and Giorgio Barletta and Daniela Grimaldi and Giulia Pierangeli and Pietro Cortelli",
year = "2009",
language = "English",
volume = "27",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",
number = "3 SUPPL. 54",

}

TY - JOUR

T1 - Evidence of a selective nociceptive impairment in systemic sclerosis

AU - Bajocchi, Gianluigi

AU - Terlizzi, Rossana

AU - Zanigni, Stefano

AU - Barletta, Giorgio

AU - Grimaldi, Daniela

AU - Pierangeli, Giulia

AU - Cortelli, Pietro

PY - 2009

Y1 - 2009

N2 - Objective. To test for the autonomic neuropathy in systemic sclerosis (SSc) using cardiovascular reflex evaluation including the "cold face test", which elicits forehead cold receptors (C-fibres). These tests examine the induced bradycardia-hypertensive response and the integrity of nociceptive afferent and parasympathetic-sympathetic efferent pathways. Methods. Twelve SSc patients were studied; including 5 with the limited cutaneous (lcSSc) involvement, and 7 with diffuse cutaneous involvement (dcSSc). All patients were matched with healthy controls. We performed cardiovascular autonomic tests (tilt-test, Valsalva manoeuver, deep breathing, sustained handgrip and cold face) with continuous monitoring of beat-to-beat blood pressure (BP) and heart rate (HR). Baroreceptor sensitivity index (BRSI) and power spectral analysis (PSA) of heart rate variability (HRV) were also evaluated. Results. SSc patients showed a statistically significant higher HR at rest (p

AB - Objective. To test for the autonomic neuropathy in systemic sclerosis (SSc) using cardiovascular reflex evaluation including the "cold face test", which elicits forehead cold receptors (C-fibres). These tests examine the induced bradycardia-hypertensive response and the integrity of nociceptive afferent and parasympathetic-sympathetic efferent pathways. Methods. Twelve SSc patients were studied; including 5 with the limited cutaneous (lcSSc) involvement, and 7 with diffuse cutaneous involvement (dcSSc). All patients were matched with healthy controls. We performed cardiovascular autonomic tests (tilt-test, Valsalva manoeuver, deep breathing, sustained handgrip and cold face) with continuous monitoring of beat-to-beat blood pressure (BP) and heart rate (HR). Baroreceptor sensitivity index (BRSI) and power spectral analysis (PSA) of heart rate variability (HRV) were also evaluated. Results. SSc patients showed a statistically significant higher HR at rest (p

KW - Cardiovascular autonomic dysfunction

KW - Heart rate variability

KW - Raynaud's phenomenon

KW - Small fibres neuropathy

KW - Systemic sclerosis

UR - http://www.scopus.com/inward/record.url?scp=70350317489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350317489&partnerID=8YFLogxK

M3 - Article

VL - 27

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 3 SUPPL. 54

ER -