Evidence of altered structural and secretory glycoconjugates in the jejunal mucosa of patients with gluten sensitive enteropathy and subtotal villous atrophy

M. Vecchi, G. Torgano, R. De Franchis, S. Tronconi, D. Agape, G. Ronchi

Research output: Contribution to journalArticlepeer-review

Abstract

The pattern of lectin histochemistry in formalin fixed, paraffin embedded normal jejunal and subtotal villous atrophy specimens from patients with gluten sensitive enteropathy were compared. There was no significant difference in the binding pattern of five lectins (Arachis hypogaea, Canavalia ensiformis, Lens culinaris, Phaseolus vulgaris and Triticum vulgaris) between normal and abnormal specimens. There were significant changes in the binding pattern of three lectins (Dolichos biflorus, Ulex europaeus, Ricinus communis), with special reference to goblet cells staining. These changes were present in all the specimens studied, regardless of the clinical diagnosis of dermatitis herpetiformis or coeliac disease. Dolichos biflorus reactive goblet cells were significantly decreased (p

Original languageEnglish
Pages (from-to)804-810
Number of pages7
JournalGut
Volume30
Issue number6
Publication statusPublished - Jun 1989

ASJC Scopus subject areas

  • Gastroenterology

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