Evidence of catalase mimetic activity in Ce3+/Ce4+ doped bioactive glasses

Valentina Nicolini, Elisa Gambuzzi, Gianluca Malavasi, Ledi Menabue, Maria Cristina Menziani, Gigliola Lusvardi, Alfonso Pedone, Francesco Benedetti, Paola Luches, Sergio D'Addato, Sergio Valeri

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The ability of Ce-containing bioactive glasses to inhibit oxidative stress in terms of reduction of hydrogen peroxide, by mimicking the catalase enzyme activity is demonstrated here for the first time. The antioxidant properties of three bioactive glasses containing an increasing amount of CeO2 have been evaluated by following the degradation of hydrogen peroxide with time after immersion in H2O2 aqueous solutions with different concentration. XPS and UV-vis measurements allowed us to determine the Ce3+/Ce4+ ratio in the bulk and on the glass surface, and to correlate it with the ability of the samples to show catalase mimetic activity. Interestingly, we have found that the bioactive glass with composition 23.2Na2O-25.7CaO-43.4SiO2-2.4P2O5-5.3CeO2 immersed in 0.1 M H2O2 aqueous solution is able to degrade 90% of it in 1 week. The reduction in bioactivity of the glasses with increasing CeO2 content is here rationalized in terms of a lower amount of phosphate groups available for the hydroxyapatite layer formation, after binding with cerium ions. In fact, classical molecular dynamics simulations revealed that the addition of CeO2 leads to the formation of cerium phosphate rich regions. The formation of an insoluble CePO4 crystalline phase is also observed by XRD analysis after thermal treatment of the glass samples.

Original languageEnglish
Pages (from-to)4009-4019
Number of pages11
JournalJournal of Physical Chemistry B
Volume119
Issue number10
DOIs
Publication statusPublished - Mar 12 2015

Fingerprint

catalase
Bioactive glass
activity (biology)
Catalase
Glass
Cerium
Hydrogen peroxide
Hydrogen Peroxide
glass
Phosphates
Oxidative stress
Enzyme activity
Durapatite
Bioactivity
Antioxidants
cerium
hydrogen peroxide
Hydroxyapatite
Molecular dynamics
phosphates

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Medicine(all)

Cite this

Nicolini, V., Gambuzzi, E., Malavasi, G., Menabue, L., Menziani, M. C., Lusvardi, G., ... Valeri, S. (2015). Evidence of catalase mimetic activity in Ce3+/Ce4+ doped bioactive glasses. Journal of Physical Chemistry B, 119(10), 4009-4019. https://doi.org/10.1021/jp511737b

Evidence of catalase mimetic activity in Ce3+/Ce4+ doped bioactive glasses. / Nicolini, Valentina; Gambuzzi, Elisa; Malavasi, Gianluca; Menabue, Ledi; Menziani, Maria Cristina; Lusvardi, Gigliola; Pedone, Alfonso; Benedetti, Francesco; Luches, Paola; D'Addato, Sergio; Valeri, Sergio.

In: Journal of Physical Chemistry B, Vol. 119, No. 10, 12.03.2015, p. 4009-4019.

Research output: Contribution to journalArticle

Nicolini, V, Gambuzzi, E, Malavasi, G, Menabue, L, Menziani, MC, Lusvardi, G, Pedone, A, Benedetti, F, Luches, P, D'Addato, S & Valeri, S 2015, 'Evidence of catalase mimetic activity in Ce3+/Ce4+ doped bioactive glasses', Journal of Physical Chemistry B, vol. 119, no. 10, pp. 4009-4019. https://doi.org/10.1021/jp511737b
Nicolini V, Gambuzzi E, Malavasi G, Menabue L, Menziani MC, Lusvardi G et al. Evidence of catalase mimetic activity in Ce3+/Ce4+ doped bioactive glasses. Journal of Physical Chemistry B. 2015 Mar 12;119(10):4009-4019. https://doi.org/10.1021/jp511737b
Nicolini, Valentina ; Gambuzzi, Elisa ; Malavasi, Gianluca ; Menabue, Ledi ; Menziani, Maria Cristina ; Lusvardi, Gigliola ; Pedone, Alfonso ; Benedetti, Francesco ; Luches, Paola ; D'Addato, Sergio ; Valeri, Sergio. / Evidence of catalase mimetic activity in Ce3+/Ce4+ doped bioactive glasses. In: Journal of Physical Chemistry B. 2015 ; Vol. 119, No. 10. pp. 4009-4019.
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