Evidence of chromosomal fragile sites in schizophrenic patients

G. Garofalo, R. M. Ragusa, A. Argiolas, C. Scavuzzo, E. Spina, C. Barletta

Research output: Contribution to journalArticlepeer-review


Chromosomal fragility and other chromosomal abnormalities were frequently observed in subjects with neuropsychiatric disorders, such as fragile X syndrome, autism or schizophrenia, but only for the first one the fragility is accepted to be associated to a specifical pathology, so that it is used as a diagnostic marker. In this study the authors analyzed 50 schizophrenic males, searching for the rare fragile sites or other aberrations with the method suitable for fra(X) detection. Chromosomes from schizophrenic patients resulted more fragile than those from normal controls, especially chromosome 9. The authors discuss the implications of a possible association of these data with the aetiopathogenesis of schizophrenic syndrome.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalAnnales de Genetique
Issue number2
Publication statusPublished - 1993


  • chromosome 9
  • rare fragile sites
  • schizophrenia

ASJC Scopus subject areas

  • Genetics


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