Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites

Massimo Pozzi, Stefano Carugo, Giuseppe Boari, Valeria Pecci, Sergio De Ceglia, Stefano Maggiolini, Gian Battista Bolla, Luigi Roffi, Monica Failla, Guido Grassi, Cristina Giannattasio, Giuseppe Mancia

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Cirrhosis is associated with cardiovascular abnormalities. Scanty information is available as to whether these include left ventricle diastolic dysfunction and wall thickness increase. To this aim in 27 cirrhotic patients with tense ascites, 17 cirrhotic patients with previous episodes of ascites (not actual), and 11 controls we investigated by echocardiography and echocolor Doppler left ventricle diastolic function (E wave, A wave, E/A ratio, deceleration time of E wave), systolic function (ejection fraction), and wall thickness (left ventricle posterior wall thickness + interventricular septum thickness) along with neurohumoral variables. All measurements (supine position) were repeated after total paracentesis (10.7 ± 0.6 L of ascites) in ascitic patients. Both in patients with and without ascites E/A ratio was reduced as compared with controls (0.93 ± 0.07 and 0.97 ± 0.06 vs. 1.18 ± 0.08, P <.05) while left ventricle wall thickness was increased (18.6 ± 0.6 and 20.1 ± 0.8 vs. 17.2 ± 0.7, P <.05 and P <.01, respectively), irrespective of the postviral or alcoholic cause of liver disease. In all cirrhotics both right and left atrial and right ventricle diameters were significantly greater. Ejection fraction was slightly but significantly (P <.01) reduced in ascitic patients. Paracentesis induced a reduction of the highly increased basal plasma renin activity, aldosterone, norepinephrine (P <.01), and epinephrine (P <.05) and improved diastolic function (E/A, P <.05). Systolic function was unaffected. Thus, irrespective of ascites and cause, advanced cirrhosis is associated with left ventricle diastolic dysfunction and wall thickness increase. We can speculate that neurohumoral overactivity, known to stimulate cardiac tissue growth, may challenge the heart, promoting fibrosis and exerting a further hindrance to ventricular relaxation in patients with cirrhosis experiencing episodes of ascites.

Original languageEnglish
Pages (from-to)1131-1137
Number of pages7
JournalHepatology
Volume26
Issue number5
Publication statusPublished - Nov 1997

Fingerprint

Ascites
Heart Ventricles
Fibrosis
Paracentesis
Cardiovascular Abnormalities
Alcoholic Liver Diseases
Deceleration
Doppler Echocardiography
Supine Position
Aldosterone
Renin
Epinephrine
Norepinephrine
Growth

ASJC Scopus subject areas

  • Hepatology

Cite this

Pozzi, M., Carugo, S., Boari, G., Pecci, V., De Ceglia, S., Maggiolini, S., ... Mancia, G. (1997). Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatology, 26(5), 1131-1137.

Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. / Pozzi, Massimo; Carugo, Stefano; Boari, Giuseppe; Pecci, Valeria; De Ceglia, Sergio; Maggiolini, Stefano; Bolla, Gian Battista; Roffi, Luigi; Failla, Monica; Grassi, Guido; Giannattasio, Cristina; Mancia, Giuseppe.

In: Hepatology, Vol. 26, No. 5, 11.1997, p. 1131-1137.

Research output: Contribution to journalArticle

Pozzi, M, Carugo, S, Boari, G, Pecci, V, De Ceglia, S, Maggiolini, S, Bolla, GB, Roffi, L, Failla, M, Grassi, G, Giannattasio, C & Mancia, G 1997, 'Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites', Hepatology, vol. 26, no. 5, pp. 1131-1137.
Pozzi M, Carugo S, Boari G, Pecci V, De Ceglia S, Maggiolini S et al. Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatology. 1997 Nov;26(5):1131-1137.
Pozzi, Massimo ; Carugo, Stefano ; Boari, Giuseppe ; Pecci, Valeria ; De Ceglia, Sergio ; Maggiolini, Stefano ; Bolla, Gian Battista ; Roffi, Luigi ; Failla, Monica ; Grassi, Guido ; Giannattasio, Cristina ; Mancia, Giuseppe. / Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. In: Hepatology. 1997 ; Vol. 26, No. 5. pp. 1131-1137.
@article{64a62c9830044518a0e92a40a97e7777,
title = "Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites",
abstract = "Cirrhosis is associated with cardiovascular abnormalities. Scanty information is available as to whether these include left ventricle diastolic dysfunction and wall thickness increase. To this aim in 27 cirrhotic patients with tense ascites, 17 cirrhotic patients with previous episodes of ascites (not actual), and 11 controls we investigated by echocardiography and echocolor Doppler left ventricle diastolic function (E wave, A wave, E/A ratio, deceleration time of E wave), systolic function (ejection fraction), and wall thickness (left ventricle posterior wall thickness + interventricular septum thickness) along with neurohumoral variables. All measurements (supine position) were repeated after total paracentesis (10.7 ± 0.6 L of ascites) in ascitic patients. Both in patients with and without ascites E/A ratio was reduced as compared with controls (0.93 ± 0.07 and 0.97 ± 0.06 vs. 1.18 ± 0.08, P <.05) while left ventricle wall thickness was increased (18.6 ± 0.6 and 20.1 ± 0.8 vs. 17.2 ± 0.7, P <.05 and P <.01, respectively), irrespective of the postviral or alcoholic cause of liver disease. In all cirrhotics both right and left atrial and right ventricle diameters were significantly greater. Ejection fraction was slightly but significantly (P <.01) reduced in ascitic patients. Paracentesis induced a reduction of the highly increased basal plasma renin activity, aldosterone, norepinephrine (P <.01), and epinephrine (P <.05) and improved diastolic function (E/A, P <.05). Systolic function was unaffected. Thus, irrespective of ascites and cause, advanced cirrhosis is associated with left ventricle diastolic dysfunction and wall thickness increase. We can speculate that neurohumoral overactivity, known to stimulate cardiac tissue growth, may challenge the heart, promoting fibrosis and exerting a further hindrance to ventricular relaxation in patients with cirrhosis experiencing episodes of ascites.",
author = "Massimo Pozzi and Stefano Carugo and Giuseppe Boari and Valeria Pecci and {De Ceglia}, Sergio and Stefano Maggiolini and Bolla, {Gian Battista} and Luigi Roffi and Monica Failla and Guido Grassi and Cristina Giannattasio and Giuseppe Mancia",
year = "1997",
month = "11",
language = "English",
volume = "26",
pages = "1131--1137",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites

AU - Pozzi, Massimo

AU - Carugo, Stefano

AU - Boari, Giuseppe

AU - Pecci, Valeria

AU - De Ceglia, Sergio

AU - Maggiolini, Stefano

AU - Bolla, Gian Battista

AU - Roffi, Luigi

AU - Failla, Monica

AU - Grassi, Guido

AU - Giannattasio, Cristina

AU - Mancia, Giuseppe

PY - 1997/11

Y1 - 1997/11

N2 - Cirrhosis is associated with cardiovascular abnormalities. Scanty information is available as to whether these include left ventricle diastolic dysfunction and wall thickness increase. To this aim in 27 cirrhotic patients with tense ascites, 17 cirrhotic patients with previous episodes of ascites (not actual), and 11 controls we investigated by echocardiography and echocolor Doppler left ventricle diastolic function (E wave, A wave, E/A ratio, deceleration time of E wave), systolic function (ejection fraction), and wall thickness (left ventricle posterior wall thickness + interventricular septum thickness) along with neurohumoral variables. All measurements (supine position) were repeated after total paracentesis (10.7 ± 0.6 L of ascites) in ascitic patients. Both in patients with and without ascites E/A ratio was reduced as compared with controls (0.93 ± 0.07 and 0.97 ± 0.06 vs. 1.18 ± 0.08, P <.05) while left ventricle wall thickness was increased (18.6 ± 0.6 and 20.1 ± 0.8 vs. 17.2 ± 0.7, P <.05 and P <.01, respectively), irrespective of the postviral or alcoholic cause of liver disease. In all cirrhotics both right and left atrial and right ventricle diameters were significantly greater. Ejection fraction was slightly but significantly (P <.01) reduced in ascitic patients. Paracentesis induced a reduction of the highly increased basal plasma renin activity, aldosterone, norepinephrine (P <.01), and epinephrine (P <.05) and improved diastolic function (E/A, P <.05). Systolic function was unaffected. Thus, irrespective of ascites and cause, advanced cirrhosis is associated with left ventricle diastolic dysfunction and wall thickness increase. We can speculate that neurohumoral overactivity, known to stimulate cardiac tissue growth, may challenge the heart, promoting fibrosis and exerting a further hindrance to ventricular relaxation in patients with cirrhosis experiencing episodes of ascites.

AB - Cirrhosis is associated with cardiovascular abnormalities. Scanty information is available as to whether these include left ventricle diastolic dysfunction and wall thickness increase. To this aim in 27 cirrhotic patients with tense ascites, 17 cirrhotic patients with previous episodes of ascites (not actual), and 11 controls we investigated by echocardiography and echocolor Doppler left ventricle diastolic function (E wave, A wave, E/A ratio, deceleration time of E wave), systolic function (ejection fraction), and wall thickness (left ventricle posterior wall thickness + interventricular septum thickness) along with neurohumoral variables. All measurements (supine position) were repeated after total paracentesis (10.7 ± 0.6 L of ascites) in ascitic patients. Both in patients with and without ascites E/A ratio was reduced as compared with controls (0.93 ± 0.07 and 0.97 ± 0.06 vs. 1.18 ± 0.08, P <.05) while left ventricle wall thickness was increased (18.6 ± 0.6 and 20.1 ± 0.8 vs. 17.2 ± 0.7, P <.05 and P <.01, respectively), irrespective of the postviral or alcoholic cause of liver disease. In all cirrhotics both right and left atrial and right ventricle diameters were significantly greater. Ejection fraction was slightly but significantly (P <.01) reduced in ascitic patients. Paracentesis induced a reduction of the highly increased basal plasma renin activity, aldosterone, norepinephrine (P <.01), and epinephrine (P <.05) and improved diastolic function (E/A, P <.05). Systolic function was unaffected. Thus, irrespective of ascites and cause, advanced cirrhosis is associated with left ventricle diastolic dysfunction and wall thickness increase. We can speculate that neurohumoral overactivity, known to stimulate cardiac tissue growth, may challenge the heart, promoting fibrosis and exerting a further hindrance to ventricular relaxation in patients with cirrhosis experiencing episodes of ascites.

UR - http://www.scopus.com/inward/record.url?scp=12644271202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12644271202&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 1131

EP - 1137

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 5

ER -