Evidence of Impaired Brain Activity Balance after Passive Sensorimotor Stimulation in Multiple Sclerosis

Nikolaos Petsas, Emanuele Tinelli, Delia Lenzi, Valentina Tomassini, Emilia Sbardella, Francesca Tona, Eytan Raz, Valter Nucciarelli, Carlo Pozzilli, Patrizia Pantano

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives:Examination of sensorimotor activation alone in multiple sclerosis (MS) patients may not yield a comprehensive view of cerebral response to task stimulation. Additional information may be obtained by examining the negative BOLD response (deactivation). Aim of this work was to characterize activation and deactivation patterns during passive hand movements in MS patients.Methods:13 relapsing remitting-MS patients (RRMS), 18 secondary progressive-MS patients (SPMS) and 15 healthy controls (HC) underwent an fMRI study during passive right-hand movements. Activation and deactivation contrasts in the three groups were entered into ANOVA, age and gender corrected. Post-hoc analysis was performed with one-sample and two-sample t-tests. For each patient we obtained lesion volume (LV) from both T1- and T2-weighted images.Results:Activations showed a progressive extension to the ipsilateral brain hemisphere according to the group and the clinical form (HC

Original languageEnglish
Article numbere65315
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 14 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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