Evidence of impaired longitudinal strain in pre-Fontan palliation in functional single left ventricle

Alessia Del Pasqua, Marcello Chinali, Carolina D'Anna, Paolo Ciliberti, Claudia Esposito, Maria Gugliotta, Priscilla Milewski, Marco Alfonso Perrone, Francesco Romeo, Adriano Carotti, Paolo Guccione, Gabriele Rinelli

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: We evaluated two-dimensional speckle-tracking echocardiography longitudinal strain (L2DSE) in functionally single left ventricles (LV).

METHODS: We retrospectively analyzed 21 patients with functionally single LV. We divided patients into two groups according to pre-Fontan cardiac catheterization data: group 1, adequate data for Fontan procedure and group 2, inadequate data.

RESULTS: LV strain correlated with predicted pressure in the Fontan system (r = 0.64; P = 0.003), pressure in the Glenn system (r = 0.57; P = 0.010), and transpulmonary gradient (r = 0.59; P = 0.008), but not with left atrial pressure (r = 0.292; P = 0.226) or ejection fraction (r = 0.254; P = 0.294). In multiple regression analysis, four-chamber LV strain was correlated with predicted pressure in the Fontan (β = 0.642: P = 0.003), whereas no association was found with LV ejection fraction (β = 0.254; P = 0.294), or time from Glenn palliation (β = 0.082; P = 0.893). When dividing the population into two groups according to catheterization data, significantly lower four-chamber longitudinal 2DSE (-25.8 ± 3.2 vs.-19.5 ± 5.1; P = 0.004) was found to be not suitable for the Fontan procedure, as compared with those who underwent successful Fontan completion.

CONCLUSION: Regardless of ejection fraction, four-chamber L2DSE is associated with high predicted pressure in the Fontan system. Patients with hemodynamic data unsuitable for Fontan operation have significantly lower mean longitudinal strain parameters. 2DSE may represent a valuable tool in assessing patients with single LV physiology and might provide useful pre-Fontan information.

Original languageEnglish
Pages (from-to)833-836
Number of pages4
JournalJournal of cardiovascular medicine (Hagerstown, Md.)
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2019

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