Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

Sergio Demarini; Bonny L. Specker; Rosa I. Sierra; Menachem Miodovnik; Reginald C. Tsang

doi:10.1016/S0022-3476(95)70414-0

Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

Sergio Demarini, Bonny L. Specker, Rosa I. Sierra, Menachem Miodovnik, Reginald C. Tsang

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).

Original language	English
Pages (from-to)	796-798
Number of pages	3
Journal	Journal of Pediatrics
Volume	126
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(95)70414-0
Publication status	Published - 1995

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes",

abstract = "Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).",

author = "Sergio Demarini and Specker, {Bonny L.} and Sierra, {Rosa I.} and Menachem Miodovnik and Tsang, {Reginald C.}",

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T1 - Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

AU - Demarini, Sergio

AU - Specker, Bonny L.

AU - Sierra, Rosa I.

AU - Miodovnik, Menachem

AU - Tsang, Reginald C.

PY - 1995

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AB - Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).

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