Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

Sergio Demarini, Bonny L. Specker, Rosa I. Sierra, Menachem Miodovnik, Reginald C. Tsang

Research output: Contribution to journalArticlepeer-review

Abstract

Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).

Original languageEnglish
Pages (from-to)796-798
Number of pages3
JournalJournal of Pediatrics
Volume126
Issue number5
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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