Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

Sergio Demarini, Bonny L. Specker, Rosa I. Sierra, Menachem Miodovnik, Reginald C. Tsang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).

Original languageEnglish
Pages (from-to)796-798
Number of pages3
JournalJournal of Pediatrics
Volume126
Issue number5
DOIs
Publication statusPublished - 1995

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Bone Resorption
Mothers
Insulin
Collagen Type I
Fetal Blood
Osteogenesis
Bone Density
Parturition
procollagen type I carboxy terminal peptide

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes. / Demarini, Sergio; Specker, Bonny L.; Sierra, Rosa I.; Miodovnik, Menachem; Tsang, Reginald C.

In: Journal of Pediatrics, Vol. 126, No. 5, 1995, p. 796-798.

Research output: Contribution to journalArticle

Demarini, Sergio ; Specker, Bonny L. ; Sierra, Rosa I. ; Miodovnik, Menachem ; Tsang, Reginald C. / Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes. In: Journal of Pediatrics. 1995 ; Vol. 126, No. 5. pp. 796-798.
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