TY - JOUR
T1 - Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes
AU - Demarini, Sergio
AU - Specker, Bonny L.
AU - Sierra, Rosa I.
AU - Miodovnik, Menachem
AU - Tsang, Reginald C.
PY - 1995
Y1 - 1995
N2 - Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).
AB - Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8).
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U2 - 10.1016/S0022-3476(95)70414-0
DO - 10.1016/S0022-3476(95)70414-0
M3 - Article
C2 - 7752009
AN - SCOPUS:0029019032
VL - 126
SP - 796
EP - 798
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -