Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis

Francesco Angelucci, Massimiliano Mirabella, Marcella Caggiula, Giovanni Frisullo, Katia Patanella, Cristina Sancricca, Viviana Nociti, Pietro Attilio Tonali, Anna Paola Batocchi

Research output: Contribution to journalArticle

Abstract

Leptin is a peptide hormone which acts on cells of immune system by influencing the production of cytokines. Serum leptin levels and cytokine production by peripheral blood mononuclear cells (PBMC) were measured in 18 secondary progressive multiple sclerosis (SPMS) patients under IFN-beta-1b treatment. There were no overall effects on leptin, interleukin-6 (IL-6), IL-10 and IL-12 p40 after 2, 6 and 12 months of treatment. However, leptin and IL-6 decreased after 6 and 12 months of treatment in 12 patients who did not show progression of disability. Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC.

Original languageEnglish
Pages (from-to)2289-2293
Number of pages5
JournalPeptides
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Cytokines
  • IL-6
  • Interferon-beta
  • Leptin
  • Secondary progressive multiple sclerosis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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    Angelucci, F., Mirabella, M., Caggiula, M., Frisullo, G., Patanella, K., Sancricca, C., Nociti, V., Tonali, P. A., & Batocchi, A. P. (2005). Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis. Peptides, 26(11), 2289-2293. https://doi.org/10.1016/j.peptides.2005.03.037