Abstract
This study investigated the effect of chronic neuroleptic therapy on hepatic glutathione concentration in relation to lipid peroxidation. Hepatic malondialdehyde (MDA) and glutathione (GSH) concentrations were measured in liver biopsies from a group of patients receiving chronic psychotropic drug therapy. The results were compared with values obtained from a selected group of controls and correlated to liver histology and blood biochemistry. Patients taking neuroleptics exhibited increased hepatic MDA and decreased total GSH levels when compared with controls. The reduction of GSH was accompanied by a 25% increase in oxidized glutathione (GSSG) concentrations. In addition, a positive correlation between liver MDA and GSSG concentrations was observed in the group receiving neuroleptic therapy. The study results suggest that an increased lipid peroxidation may represent a contributory mechanism for neuroleptic drug toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 133-141 |
| Number of pages | 9 |
| Journal | Current Therapeutic Research |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 |
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Evidence of lipid peroxidation in patients taking neuroleptic drugs. / Vendemiale, Gianluigi; Portincasa, Piero; Palasciano, Giuseppe; Altomare, Emanuele.
In: Current Therapeutic Research, Vol. 55, No. 2, 1994, p. 133-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence of lipid peroxidation in patients taking neuroleptic drugs
AU - Vendemiale, Gianluigi
AU - Portincasa, Piero
AU - Palasciano, Giuseppe
AU - Altomare, Emanuele
PY - 1994
Y1 - 1994
N2 - This study investigated the effect of chronic neuroleptic therapy on hepatic glutathione concentration in relation to lipid peroxidation. Hepatic malondialdehyde (MDA) and glutathione (GSH) concentrations were measured in liver biopsies from a group of patients receiving chronic psychotropic drug therapy. The results were compared with values obtained from a selected group of controls and correlated to liver histology and blood biochemistry. Patients taking neuroleptics exhibited increased hepatic MDA and decreased total GSH levels when compared with controls. The reduction of GSH was accompanied by a 25% increase in oxidized glutathione (GSSG) concentrations. In addition, a positive correlation between liver MDA and GSSG concentrations was observed in the group receiving neuroleptic therapy. The study results suggest that an increased lipid peroxidation may represent a contributory mechanism for neuroleptic drug toxicity.
AB - This study investigated the effect of chronic neuroleptic therapy on hepatic glutathione concentration in relation to lipid peroxidation. Hepatic malondialdehyde (MDA) and glutathione (GSH) concentrations were measured in liver biopsies from a group of patients receiving chronic psychotropic drug therapy. The results were compared with values obtained from a selected group of controls and correlated to liver histology and blood biochemistry. Patients taking neuroleptics exhibited increased hepatic MDA and decreased total GSH levels when compared with controls. The reduction of GSH was accompanied by a 25% increase in oxidized glutathione (GSSG) concentrations. In addition, a positive correlation between liver MDA and GSSG concentrations was observed in the group receiving neuroleptic therapy. The study results suggest that an increased lipid peroxidation may represent a contributory mechanism for neuroleptic drug toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0028355319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028355319&partnerID=8YFLogxK
U2 - 10.1016/S0011-393X(05)80685-X
DO - 10.1016/S0011-393X(05)80685-X
M3 - Article
AN - SCOPUS:0028355319
VL - 55
SP - 133
EP - 141
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 2
ER -