Evidence of lower oxidative stress in the air spaces of patients with reversible COPD

G. Serviddio, G. E. Carpagnano, T. Rollo, R. Tamborra, M. P. Foschino Barbaro, G. Vendemiale, Emanuele Altomare

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The mechanism responsible for the reversibility of airflow limitation in stable chronic obstructive pulmonary disease (COPD) patients is unknown. The aim of this study is to assess the relationship between the reversibility of airflow limitation, the redox balance and the inflammatory cells in the sputum of patients with stable COPD. For this purpose we examined 15 normal healthy control subjects and 20 nonatopic COPD patients. The COPD patients were divided into two groups: reversible COPD (increase in FEV 1>200 ml and/or ≥12% after 200 μg of inhaled salbutamol) or non-reversible COPD. GSH, GSSG were measured in induced sputum and blood. Protein carbonyls were evaluated by WB in sputum and IL-4 and IL-6 and TNF-α in plasma and sputum. GSH oxidation and protein oxidation were lower in reversible COPD patients than in those with no reversibility. The sputum eosinophil count was significantly higher in the reversible group than in the non-reversible group, and IL-4 concentration was higher in the same patients both in sputum and in plasma. In contrast, IL-6 and TNF-α were increased in non-reversible COPD patients in both biological samples. We conclude that airflow reversibility in COPD patients is associated with airway oxidative stress and activation of eosinophil inflammatory pattern in sputum and blood, suggesting that these patients could respond to specific pharmacological treatment.

Original languageEnglish
Pages (from-to)617-628
Number of pages12
JournalInternational Journal of Immunopathology and Pharmacology
Volume19
Issue number3
Publication statusPublished - Jul 2006

Fingerprint

Chronic Obstructive Pulmonary Disease
Oxidative Stress
Sputum
Air
Eosinophils
Interleukin-4
Interleukin-6
Glutathione Disulfide
Albuterol
Oxidation-Reduction
Healthy Volunteers
Proteins
Pharmacology

Keywords

  • β-2 agonist reversibility
  • COPD
  • Glutathione
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology

Cite this

Serviddio, G., Carpagnano, G. E., Rollo, T., Tamborra, R., Foschino Barbaro, M. P., Vendemiale, G., & Altomare, E. (2006). Evidence of lower oxidative stress in the air spaces of patients with reversible COPD. International Journal of Immunopathology and Pharmacology, 19(3), 617-628.

Evidence of lower oxidative stress in the air spaces of patients with reversible COPD. / Serviddio, G.; Carpagnano, G. E.; Rollo, T.; Tamborra, R.; Foschino Barbaro, M. P.; Vendemiale, G.; Altomare, Emanuele.

In: International Journal of Immunopathology and Pharmacology, Vol. 19, No. 3, 07.2006, p. 617-628.

Research output: Contribution to journalArticle

Serviddio, G, Carpagnano, GE, Rollo, T, Tamborra, R, Foschino Barbaro, MP, Vendemiale, G & Altomare, E 2006, 'Evidence of lower oxidative stress in the air spaces of patients with reversible COPD', International Journal of Immunopathology and Pharmacology, vol. 19, no. 3, pp. 617-628.
Serviddio G, Carpagnano GE, Rollo T, Tamborra R, Foschino Barbaro MP, Vendemiale G et al. Evidence of lower oxidative stress in the air spaces of patients with reversible COPD. International Journal of Immunopathology and Pharmacology. 2006 Jul;19(3):617-628.
Serviddio, G. ; Carpagnano, G. E. ; Rollo, T. ; Tamborra, R. ; Foschino Barbaro, M. P. ; Vendemiale, G. ; Altomare, Emanuele. / Evidence of lower oxidative stress in the air spaces of patients with reversible COPD. In: International Journal of Immunopathology and Pharmacology. 2006 ; Vol. 19, No. 3. pp. 617-628.
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