Evidence of multifocal activity of coronary disease in patients with acute myocardial infarction

Maurizio D. Guazzi, Maurizio Bussotti, Luca Grancini, Nicoletta De Cesare, Marco Guazzi, Isidoro L. Pera, Alessandro Loaldi

Research output: Contribution to journalArticle

Abstract

Background: Destabilization of the fibrous cap facilitates plaque rupture, thrombus formation, and myocardial infarction. Because systemic stimuli such as lipoproteins infectious agents, and autoantigens, may incite this reaction, one may wonder whether disruption mechanisms are only local or systemic and infarction is caused by an arbitrary plaque event or by a systemic, acute activity of the coronary disease. Methods and Results: Early (3 to 5 days) and late (1 month) peri-infarction coronary angiographic data in 23 patients with first infarction. Were compared with that in 23 similar patients, with angiography performed because of stable angina and repeated after, 1 month before angioplasty. Nonculprit lesion changes at the narrowest point defined progression or regression when exceeding 0.27 mm. In patients with recent infarction we found that 16 had progression, 4 had regression, 1 had both, 2 were steady (values in patients with stable angina being 2 [P

Original languageEnglish
Pages (from-to)1145-1151
Number of pages7
JournalCirculation
Volume96
Issue number4
Publication statusPublished - Aug 19 1997

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Infarction
Coronary Disease
Myocardial Infarction
Stable Angina
Autoantigens
Angioplasty
Lipoproteins
Rupture
Angiography
Thrombosis

Keywords

  • Angina
  • Myocardial infarction
  • Plaque
  • Remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Evidence of multifocal activity of coronary disease in patients with acute myocardial infarction. / Guazzi, Maurizio D.; Bussotti, Maurizio; Grancini, Luca; De Cesare, Nicoletta; Guazzi, Marco; Pera, Isidoro L.; Loaldi, Alessandro.

In: Circulation, Vol. 96, No. 4, 19.08.1997, p. 1145-1151.

Research output: Contribution to journalArticle

Guazzi, Maurizio D. ; Bussotti, Maurizio ; Grancini, Luca ; De Cesare, Nicoletta ; Guazzi, Marco ; Pera, Isidoro L. ; Loaldi, Alessandro. / Evidence of multifocal activity of coronary disease in patients with acute myocardial infarction. In: Circulation. 1997 ; Vol. 96, No. 4. pp. 1145-1151.
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AU - Bussotti, Maurizio

AU - Grancini, Luca

AU - De Cesare, Nicoletta

AU - Guazzi, Marco

AU - Pera, Isidoro L.

AU - Loaldi, Alessandro

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AB - Background: Destabilization of the fibrous cap facilitates plaque rupture, thrombus formation, and myocardial infarction. Because systemic stimuli such as lipoproteins infectious agents, and autoantigens, may incite this reaction, one may wonder whether disruption mechanisms are only local or systemic and infarction is caused by an arbitrary plaque event or by a systemic, acute activity of the coronary disease. Methods and Results: Early (3 to 5 days) and late (1 month) peri-infarction coronary angiographic data in 23 patients with first infarction. Were compared with that in 23 similar patients, with angiography performed because of stable angina and repeated after, 1 month before angioplasty. Nonculprit lesion changes at the narrowest point defined progression or regression when exceeding 0.27 mm. In patients with recent infarction we found that 16 had progression, 4 had regression, 1 had both, 2 were steady (values in patients with stable angina being 2 [P

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