TY - JOUR
T1 - Evidence of non-A, non-B, non-C infection in chronic hepatitis by polymerase chain raction testing for hepatitis B and C viruses
AU - Romeo, Raffaella
AU - Pol, Stanislas
AU - Demeret, Caroline
AU - Thiers, Valerie
AU - Kremsdorf, Dina
AU - Cuillerier, Emmanuel
AU - Berthelot, Pierre
AU - Brechot, Christian
PY - 1995
Y1 - 1995
N2 - Background/Aims: Although hepatitis C virus is clearly the major cause of non-A, non-B acute and chronic hepatitis, there is a group of patients with histologically documented chronic hepatitis with no serological marker of hepatitis B and C, nor any other risk factors for liver disease. Methods: We have investigated 17 well-characterized patients and chronic active hepatitis. HBV-DNA and HCV-RNA were tested by polymerase chain reaction in 17 serum samples and in six liver biopsies. Results: Four of the 17 patients had serum HCV-RNA detectable by polymerase chain reaction, while non had HBV-DNA detectable by polymerase chain reaction. Three of the six liver samples gave a positive signal by cyclin A and HLA, and only these were considered for the study. One of the three was HCV-RNA positive, while none was HBV-DNA positive. Conclusions: Our results, obtained through careful elimination of all known risk factors for liver disease, strongly suggest that non-A, non-B, non-C hepatotropic virus(es) could be involved in some cases of chronic active liver disease.
AB - Background/Aims: Although hepatitis C virus is clearly the major cause of non-A, non-B acute and chronic hepatitis, there is a group of patients with histologically documented chronic hepatitis with no serological marker of hepatitis B and C, nor any other risk factors for liver disease. Methods: We have investigated 17 well-characterized patients and chronic active hepatitis. HBV-DNA and HCV-RNA were tested by polymerase chain reaction in 17 serum samples and in six liver biopsies. Results: Four of the 17 patients had serum HCV-RNA detectable by polymerase chain reaction, while non had HBV-DNA detectable by polymerase chain reaction. Three of the six liver samples gave a positive signal by cyclin A and HLA, and only these were considered for the study. One of the three was HCV-RNA positive, while none was HBV-DNA positive. Conclusions: Our results, obtained through careful elimination of all known risk factors for liver disease, strongly suggest that non-A, non-B, non-C hepatotropic virus(es) could be involved in some cases of chronic active liver disease.
KW - Chronic hepatitis
KW - Non-A, non-B, non-C
KW - Polymerase chain reaction
UR - http://www.scopus.com/inward/record.url?scp=0028933278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028933278&partnerID=8YFLogxK
U2 - 10.1016/0168-8278(95)80418-8
DO - 10.1016/0168-8278(95)80418-8
M3 - Article
C2 - 7790699
AN - SCOPUS:0028933278
VL - 22
SP - 125
EP - 129
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 2
ER -