Evidence of p53 immunohistochemical overexpression in ethmoidal mucosa of woodworkers

Guido Valente, Luisa Ferrari, Simonetta Kerim, Carmine F. Gervasio, Eugenia Ricci, Giuseppe Migliaretti, Enrico Pira, Mario Bussi

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A high risk of neoplastic transformation of nasal and paranasal sinuses mucosa is related to the occupational exposure to wood dust, however no conclusive data have been reported up to now about morphological precursors of these tumors, mechanisms of carcinogenesis and role of p53 gene. Immunohistochemical overexpression of protein p53 (DO7 clone) by epithelial cells of ethmoidal mucosa was investigated on 60 woodworkers occupationally exposed for a minimum of 10 years, on 50 functional and/or esthetic nasal surgery patients (control group) and on 15 cases of intestinal-type adenocarcinoma, 10 of these involving subjects who had a longtime exposure to wood dust. In almost all the woodworkers (92%) the normal ciliated epithelium showed tracts of squamous metaplasia. The mean percentage of p53-positive cells in woodworkers and in controls was 28.6 and 7.97%, respectively, in metaplastic epithelium (P

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalCancer Detection and Prevention
Issue number2
Publication statusPublished - 2004


  • Immunohistochemistry
  • Intestinal-type adenocarcinoma
  • Nasal tumors
  • Occupational tumors
  • p53 gene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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