Evidence of retroviral involvement in an Italian patient with Ofuji's disease

Stefano Veraldi, P. Ferrante, R. Mancuso, R. Gianotti, R. Caputo

Research output: Contribution to journalArticle

Abstract

Ofuji's disease, also known as 'eosinophilic pustular folliculitis', is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji's disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46l) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalDermatology
Volume198
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Human T-lymphotropic virus 1
Retroviridae
Blood Cells
Glycoproteins
Polymerase Chain Reaction
Skin
Antibodies
Eosinophilic pustular folliculitis

Keywords

  • Eosinophilic pustular folliculitis
  • Human T-cell lymphotropic virus 1
  • Ofuji's disease
  • Retrovirus

ASJC Scopus subject areas

  • Dermatology

Cite this

Evidence of retroviral involvement in an Italian patient with Ofuji's disease. / Veraldi, Stefano; Ferrante, P.; Mancuso, R.; Gianotti, R.; Caputo, R.

In: Dermatology, Vol. 198, No. 1, 1999, p. 86-89.

Research output: Contribution to journalArticle

@article{c75c1e02bb9e4b06a1503057228d255c,
title = "Evidence of retroviral involvement in an Italian patient with Ofuji's disease",
abstract = "Ofuji's disease, also known as 'eosinophilic pustular folliculitis', is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji's disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46l) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.",
keywords = "Eosinophilic pustular folliculitis, Human T-cell lymphotropic virus 1, Ofuji's disease, Retrovirus",
author = "Stefano Veraldi and P. Ferrante and R. Mancuso and R. Gianotti and R. Caputo",
year = "1999",
doi = "10.1159/000018073",
language = "English",
volume = "198",
pages = "86--89",
journal = "Dermatology",
issn = "1018-8665",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Evidence of retroviral involvement in an Italian patient with Ofuji's disease

AU - Veraldi, Stefano

AU - Ferrante, P.

AU - Mancuso, R.

AU - Gianotti, R.

AU - Caputo, R.

PY - 1999

Y1 - 1999

N2 - Ofuji's disease, also known as 'eosinophilic pustular folliculitis', is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji's disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46l) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.

AB - Ofuji's disease, also known as 'eosinophilic pustular folliculitis', is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji's disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46l) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.

KW - Eosinophilic pustular folliculitis

KW - Human T-cell lymphotropic virus 1

KW - Ofuji's disease

KW - Retrovirus

UR - http://www.scopus.com/inward/record.url?scp=0032978025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032978025&partnerID=8YFLogxK

U2 - 10.1159/000018073

DO - 10.1159/000018073

M3 - Article

C2 - 10026411

AN - SCOPUS:0032978025

VL - 198

SP - 86

EP - 89

JO - Dermatology

JF - Dermatology

SN - 1018-8665

IS - 1

ER -