Evidence of retroviral involvement in an Italian patient with Ofuji's disease

Stefano Veraldi, P. Ferrante, R. Mancuso, R. Gianotti, R. Caputo

Research output: Contribution to journalArticlepeer-review

Abstract

Ofuji's disease, also known as 'eosinophilic pustular folliculitis', is a rare inflammatory skin disorder of unknown aetiology, which affects mostly adult Japanese males. Only few Caucasian patients have been described so far. We report the case of a 44-year-old Italian woman with Ofuji's disease who had circulating antibodies against the recombinant envelope glycoprotein (Rgp46l) of HTLV-1. By means of a very sensitive nested PCR, the tax region of HTLV-1, but not other regions, was found in peripheral blood mononuclear cells. Our observations suggest that a retrovirus, closely related to HTLV but not yet identified, could be involved in the pathogenesis of the disease in this patient.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalDermatology
Volume198
Issue number1
DOIs
Publication statusPublished - 1999

Keywords

  • Eosinophilic pustular folliculitis
  • Human T-cell lymphotropic virus 1
  • Ofuji's disease
  • Retrovirus

ASJC Scopus subject areas

  • Dermatology

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