TY - JOUR
T1 - Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon
AU - Tscherning-Casper, C.
AU - Dolcini, G.
AU - Mauclere, P.
AU - Fenyo, E. M.
AU - Barre-Sinoussi, F.
AU - Albert, J.
AU - Menu, E.
AU - Mbopi Keou, F. X.
AU - Ayouba, A.
AU - Tina, E.
AU - Martin, P.
AU - Athanassakis, I.
AU - Chaouat, G.
AU - Mognetti, B.
AU - Moussa, M.
AU - Lagaye, S.
AU - Scarlatti, G.
AU - Tresoldi, E.
AU - Dormont, D.
AU - Roques, P.
AU - Depienne, C.
AU - Bomsel, M.
AU - Gounon, P.
AU - Tolpilko, A.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger comfort study in Yaounde, Cameroon. Fourteen of 15 virus variants were shown to be recombinant, whereas a single variant appeared to be nonrecombinant subtype A. Five viruses were subtype A/J recombinants, with env genes derived from subtype A and protease genes derived from subtype J. Seven viruses clustered with reference sequences for CRF0-2AG(IbNG) in both the env and protease gene fragments, and were thus subtype A/G recombinants. Two variants displayed even more complex recombination patterns. Phylogenetic analyses indicated that the five subtype A/J recombinants might be the first representatives of a previously unrecognized CRF.
AB - Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger comfort study in Yaounde, Cameroon. Fourteen of 15 virus variants were shown to be recombinant, whereas a single variant appeared to be nonrecombinant subtype A. Five viruses were subtype A/J recombinants, with env genes derived from subtype A and protease genes derived from subtype J. Seven viruses clustered with reference sequences for CRF0-2AG(IbNG) in both the env and protease gene fragments, and were thus subtype A/G recombinants. Two variants displayed even more complex recombination patterns. Phylogenetic analyses indicated that the five subtype A/J recombinants might be the first representatives of a previously unrecognized CRF.
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U2 - 10.1089/08892220050117078
DO - 10.1089/08892220050117078
M3 - Article
C2 - 10957728
AN - SCOPUS:0034284925
VL - 16
SP - 1313
EP - 1318
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 13
ER -