Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon

C. Tscherning-Casper; G. Dolcini; P. Mauclere; E. M. Fenyo; F. Barre-Sinoussi; J. Albert; E. Menu; F. X. Mbopi Keou; A. Ayouba; E. Tina; P. Martin; I. Athanassakis; G. Chaouat; B. Mognetti; M. Moussa; S. Lagaye; G. Scarlatti; E. Tresoldi; D. Dormont; P. Roques; C. Depienne; M. Bomsel; P. Gounon; A. Tolpilko

doi:10.1089/08892220050117078

Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon

C. Tscherning-Casper, G. Dolcini, P. Mauclere, E. M. Fenyo, F. Barre-Sinoussi, J. Albert, E. Menu, F. X. Mbopi Keou, A. Ayouba, E. Tina, P. Martin, I. Athanassakis, G. Chaouat, B. Mognetti, M. Moussa, S. Lagaye, G. Scarlatti, E. Tresoldi, D. Dormont, P. RoquesC. Depienne, M. Bomsel, P. Gounon, A. Tolpilko

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger comfort study in Yaounde, Cameroon. Fourteen of 15 virus variants were shown to be recombinant, whereas a single variant appeared to be nonrecombinant subtype A. Five viruses were subtype A/J recombinants, with env genes derived from subtype A and protease genes derived from subtype J. Seven viruses clustered with reference sequences for CRF0-2AG(IbNG) in both the env and protease gene fragments, and were thus subtype A/G recombinants. Two variants displayed even more complex recombination patterns. Phylogenetic analyses indicated that the five subtype A/J recombinants might be the first representatives of a previously unrecognized CRF.

Original language	English
Pages (from-to)	1313-1318
Number of pages	6
Journal	AIDS Research and Human Retroviruses
Volume	16
Issue number	13
DOIs	https://doi.org/10.1089/08892220050117078
Publication status	Published - Sep 1 2000

ASJC Scopus subject areas

Immunology
Virology

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10.1089/08892220050117078

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Tscherning-Casper, C., Dolcini, G., Mauclere, P., Fenyo, E. M., Barre-Sinoussi, F., Albert, J., Menu, E., Mbopi Keou, F. X., Ayouba, A., Tina, E., Martin, P., Athanassakis, I., Chaouat, G., Mognetti, B., Moussa, M., Lagaye, S., Scarlatti, G., Tresoldi, E., Dormont, D., ... Tolpilko, A. (2000). Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. AIDS Research and Human Retroviruses, 16(13), 1313-1318. https://doi.org/10.1089/08892220050117078

Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. / Tscherning-Casper, C.; Dolcini, G.; Mauclere, P.; Fenyo, E. M.; Barre-Sinoussi, F.; Albert, J.; Menu, E.; Mbopi Keou, F. X.; Ayouba, A.; Tina, E.; Martin, P.; Athanassakis, I.; Chaouat, G.; Mognetti, B.; Moussa, M.; Lagaye, S.; Scarlatti, G.; Tresoldi, E.; Dormont, D.; Roques, P.; Depienne, C.; Bomsel, M.; Gounon, P.; Tolpilko, A.

In: AIDS Research and Human Retroviruses, Vol. 16, No. 13, 01.09.2000, p. 1313-1318.

Research output: Contribution to journal › Article › peer-review

Tscherning-Casper, C, Dolcini, G, Mauclere, P, Fenyo, EM, Barre-Sinoussi, F, Albert, J, Menu, E, Mbopi Keou, FX, Ayouba, A, Tina, E, Martin, P, Athanassakis, I, Chaouat, G, Mognetti, B, Moussa, M, Lagaye, S, Scarlatti, G, Tresoldi, E, Dormont, D, Roques, P, Depienne, C, Bomsel, M, Gounon, P & Tolpilko, A 2000, 'Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon', AIDS Research and Human Retroviruses, vol. 16, no. 13, pp. 1313-1318. https://doi.org/10.1089/08892220050117078

Tscherning-Casper, C. ; Dolcini, G. ; Mauclere, P. ; Fenyo, E. M. ; Barre-Sinoussi, F. ; Albert, J. ; Menu, E. ; Mbopi Keou, F. X. ; Ayouba, A. ; Tina, E. ; Martin, P. ; Athanassakis, I. ; Chaouat, G. ; Mognetti, B. ; Moussa, M. ; Lagaye, S. ; Scarlatti, G. ; Tresoldi, E. ; Dormont, D. ; Roques, P. ; Depienne, C. ; Bomsel, M. ; Gounon, P. ; Tolpilko, A. / Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon. In: AIDS Research and Human Retroviruses. 2000 ; Vol. 16, No. 13. pp. 1313-1318.

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AU - Dormont, D.

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AU - Depienne, C.

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