Evidence of the existence of a new circulating recombinant form of HIV type 1 subtype A/J in Cameroon

C. Tscherning-Casper, G. Dolcini, P. Mauclere, E. M. Fenyo, F. Barre-Sinoussi, J. Albert, E. Menu, F. X. Mbopi Keou, A. Ayouba, E. Tina, P. Martin, I. Athanassakis, G. Chaouat, B. Mognetti, M. Moussa, S. Lagaye, G. Scarlatti, E. Tresoldi, D. Dormont, P. RoquesC. Depienne, M. Bomsel, P. Gounon, A. Tolpilko

Research output: Contribution to journalArticlepeer-review

Abstract

Several genetic subtypes and circulating recombinant forms (CRFs) of HIV-1 have been identified. The greatest degree of genetic diversity is displayed by variants from Central and West Africa. HIV-1 env C2-V5 and protease sequences were obtained from 15 HIV-1-infected pregnant women, who were selected from a larger comfort study in Yaounde, Cameroon. Fourteen of 15 virus variants were shown to be recombinant, whereas a single variant appeared to be nonrecombinant subtype A. Five viruses were subtype A/J recombinants, with env genes derived from subtype A and protease genes derived from subtype J. Seven viruses clustered with reference sequences for CRF0-2AG(IbNG) in both the env and protease gene fragments, and were thus subtype A/G recombinants. Two variants displayed even more complex recombination patterns. Phylogenetic analyses indicated that the five subtype A/J recombinants might be the first representatives of a previously unrecognized CRF.

Original languageEnglish
Pages (from-to)1313-1318
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume16
Issue number13
DOIs
Publication statusPublished - Sep 1 2000

ASJC Scopus subject areas

  • Immunology
  • Virology

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