Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin

T. Mennini, E. Borroni, R. Samanin, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of various drugs on the release of [3H]-serotonin from synaptosomes of reserpine-treated rats was compared with that obtained with synaptosomes of untreated animals. The increase in [3H]-serotonin release induced by d-fenfluramine was virtually abolished by reserpine; the effect of d-norfenfluramine, the main metabolite of fenfluramine, was instead enhanced in synaptosomes of reserpine treated animals. [3H]-serotonin release induced by l-isomers of fenfluramine or norfenfluramine was increased or not affected, respectively, after reserpine treatment. The effects of other drugs, known to activate serotonin mechanisms such as metachlorophenylpiperazine and quipazine, like d-norfenfluramine, were increased by the reserpine treatment. The present data show that [3H]-serotonin can be released by drugs from two pools with different sensitivity to reserpine. The reserpinized synaptosomes could provide useful information on the mechanisms of action of drugs acting on brain serotonin.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalNeurochemistry International
Volume3
Issue number5
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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