Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men

Frauke Friedrichs, Sonia Brescianini, Vito Annese, Anna Latiano, Klaus Berger, Subra Kugathasan, Ulrich Broeckel, Susanna Nikolaus, Mark J. Daly, Stefan Schreiber, John D. Rioux, Monika Stoll

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, we described the association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) in a large European study sample (Stoll et al. in Nat Genet 36:476-480, 2004). Here, we report that the R30Q variant constitutes a susceptibility factor for Crohn disease (CD) in men [odds ratio (OR)=2.49, 95% confidence interval (CI) 1.53-4.06, P

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalHuman Genetics
Volume119
Issue number3
DOIs
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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