Abstract
About 90% of gastric cancer (GC) cases appear in a sporadic setting. Nonetheless, in high incidence areas high familial aggregation rates have been recently described. Microsatellite instability (MSI) is thought to be an important molecular phenotype both in sporadic GC and in tumors of the HNPCC spectrum. The aim of this study was to assess the frequency of MSI in GC with familial aggregation. Five quasimonomorphic mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21 and NR-27) were analyzed in 250 GC patients. Seventy-five patients (30%) had at least one-first-degree family member affected by GC and 63 patients (25.2%) showed MSI. The frequency of MSI was significantly higher in patients with a positive family history of GC (38.7%) compared to patients with other tumor types within the family (15.7%) or with a negative oncological familial history (21.9%, P = 0.004). Within cases with a positive familial oncological history, the MSI frequency in families with GC only was similar to the one observed in families with GC and colon cancer (P = 0.96). Nonetheless, in families with GC and lung cancer, the frequency of MSI was significantly lower (5.6%, P = 0.007). MSI occurs in GCs with familial aggregation. Similar MSI rates have been observed in GC patients with other family members affected by GC or colon cancer. The same does not occur in families with other members affected by lung cancer. Our data seem to suggest that familial aggregation for either GC alone or gastric and colon cancer share common etiological factors in contrast to families with gastric and lung cancers.
| Original language | English |
|---|---|
| Pages (from-to) | 215-220 |
| Number of pages | 6 |
| Journal | Familial Cancer |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2009 |
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Keywords
- Family history
- Gastric cancer
- Microsatellite instability
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Oncology
- Genetics(clinical)
Cite this
Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. / Pedrazzani, Corrado; Corso, Giovanni; Velho, Sérgia; Leite, Marina; Pascale, Valeria; Bettarini, Francesca; Marrelli, Daniele; Seruca, Raquel; Roviello, Franco.
In: Familial Cancer, Vol. 8, No. 3, 09.2009, p. 215-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence of tumor microsatellite instability in gastric cancer with familial aggregation
AU - Pedrazzani, Corrado
AU - Corso, Giovanni
AU - Velho, Sérgia
AU - Leite, Marina
AU - Pascale, Valeria
AU - Bettarini, Francesca
AU - Marrelli, Daniele
AU - Seruca, Raquel
AU - Roviello, Franco
PY - 2009/9
Y1 - 2009/9
N2 - About 90% of gastric cancer (GC) cases appear in a sporadic setting. Nonetheless, in high incidence areas high familial aggregation rates have been recently described. Microsatellite instability (MSI) is thought to be an important molecular phenotype both in sporadic GC and in tumors of the HNPCC spectrum. The aim of this study was to assess the frequency of MSI in GC with familial aggregation. Five quasimonomorphic mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21 and NR-27) were analyzed in 250 GC patients. Seventy-five patients (30%) had at least one-first-degree family member affected by GC and 63 patients (25.2%) showed MSI. The frequency of MSI was significantly higher in patients with a positive family history of GC (38.7%) compared to patients with other tumor types within the family (15.7%) or with a negative oncological familial history (21.9%, P = 0.004). Within cases with a positive familial oncological history, the MSI frequency in families with GC only was similar to the one observed in families with GC and colon cancer (P = 0.96). Nonetheless, in families with GC and lung cancer, the frequency of MSI was significantly lower (5.6%, P = 0.007). MSI occurs in GCs with familial aggregation. Similar MSI rates have been observed in GC patients with other family members affected by GC or colon cancer. The same does not occur in families with other members affected by lung cancer. Our data seem to suggest that familial aggregation for either GC alone or gastric and colon cancer share common etiological factors in contrast to families with gastric and lung cancers.
AB - About 90% of gastric cancer (GC) cases appear in a sporadic setting. Nonetheless, in high incidence areas high familial aggregation rates have been recently described. Microsatellite instability (MSI) is thought to be an important molecular phenotype both in sporadic GC and in tumors of the HNPCC spectrum. The aim of this study was to assess the frequency of MSI in GC with familial aggregation. Five quasimonomorphic mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21 and NR-27) were analyzed in 250 GC patients. Seventy-five patients (30%) had at least one-first-degree family member affected by GC and 63 patients (25.2%) showed MSI. The frequency of MSI was significantly higher in patients with a positive family history of GC (38.7%) compared to patients with other tumor types within the family (15.7%) or with a negative oncological familial history (21.9%, P = 0.004). Within cases with a positive familial oncological history, the MSI frequency in families with GC only was similar to the one observed in families with GC and colon cancer (P = 0.96). Nonetheless, in families with GC and lung cancer, the frequency of MSI was significantly lower (5.6%, P = 0.007). MSI occurs in GCs with familial aggregation. Similar MSI rates have been observed in GC patients with other family members affected by GC or colon cancer. The same does not occur in families with other members affected by lung cancer. Our data seem to suggest that familial aggregation for either GC alone or gastric and colon cancer share common etiological factors in contrast to families with gastric and lung cancers.
KW - Family history
KW - Gastric cancer
KW - Microsatellite instability
UR - http://www.scopus.com/inward/record.url?scp=68449100164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68449100164&partnerID=8YFLogxK
U2 - 10.1007/s10689-008-9231-7
DO - 10.1007/s10689-008-9231-7
M3 - Article
C2 - 19152022
AN - SCOPUS:68449100164
VL - 8
SP - 215
EP - 220
JO - Familial Cancer
JF - Familial Cancer
SN - 1389-9600
IS - 3
ER -