Evidence that apolipoprotein(a) phenoptype is a risk factor for coronary artery disease in men <55 years of age

Mariella Parlavecchia, Alessandra Pancaldi, Roberto Taramelli, Paola Valsania, Laura Galli, Guido Pozza, Sergio Chierchia, Giacomo Ruotolo

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Abstract

Whereas the importance of plasma lipoprotein(a) [Lp(a)] levels as a risk factor for premature coronary artery disease (CAD) is certain, it is not clear if the apolipoprotein(a) [apo(a)] phenotype plays an additional and independent role. To investigate the possible effect of apo(a) phenotype on premature CAD (in patients <55 years of age), plasma Lp(a) concentrations, the apo(a) phenotypes, and their relation with many recognized CAD risk factors were examined in 96 non-diabetic male patients with angiographically defined CAD and in 83 age-matched male control subjects with no angiographic evidence of CAD. Results demonstrate that patients with premature CAD are characterized by higher Lp(a) levels (24 ± 21 vs 17 ± 15 mg/dl, p <0.01) and a higher frequency of S2 phenotype (32% vs 15%, p <0.01). Patients with an S2 phenotype exhibited significantly higher plasma Lp(a) concentrations than control subjects with the same isoform (37 ± 22 vs 22 ± 17 mg/dl, p <0.05). A significant correlation was found between apo B and Lp(a) levels in patients with an S2 phenotype. In addition, patients had a low frequency of S1 and S4, and a high frequency of double-band phenotypes of apo(a). Muttivariate analysis did not demonstrate an independent role for apo(a) phenotype as a risk factor for premature CAD. In conclusion, CAD patients <55 years of age have a very different pattern of apo(a) phenotypes than subjects with no angiographic evidence of CAD; this study confirms the hypothesis that apo(a) phenotype may play an additional role in the etiology of premature CAD.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalThe American Journal of Cardiology
Volume74
Issue number4
DOIs
Publication statusPublished - Aug 15 1994

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Apoprotein(a)
Coronary Artery Disease
Phenotype
Lipoprotein(a)
Apolipoproteins B
Protein Isoforms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evidence that apolipoprotein(a) phenoptype is a risk factor for coronary artery disease in men <55 years of age. / Parlavecchia, Mariella; Pancaldi, Alessandra; Taramelli, Roberto; Valsania, Paola; Galli, Laura; Pozza, Guido; Chierchia, Sergio; Ruotolo, Giacomo.

In: The American Journal of Cardiology, Vol. 74, No. 4, 15.08.1994, p. 346-351.

Research output: Contribution to journalArticle

Parlavecchia, M, Pancaldi, A, Taramelli, R, Valsania, P, Galli, L, Pozza, G, Chierchia, S & Ruotolo, G 1994, 'Evidence that apolipoprotein(a) phenoptype is a risk factor for coronary artery disease in men <55 years of age', The American Journal of Cardiology, vol. 74, no. 4, pp. 346-351. https://doi.org/10.1016/0002-9149(94)90401-4
Parlavecchia, Mariella ; Pancaldi, Alessandra ; Taramelli, Roberto ; Valsania, Paola ; Galli, Laura ; Pozza, Guido ; Chierchia, Sergio ; Ruotolo, Giacomo. / Evidence that apolipoprotein(a) phenoptype is a risk factor for coronary artery disease in men <55 years of age. In: The American Journal of Cardiology. 1994 ; Vol. 74, No. 4. pp. 346-351.
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