Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test

L. Cervo, R. Samanin

Research output: Contribution to journalArticle

Abstract

Bilateral injections of 5 or 1 (but not 0.5) μg sulpiride into the nucleus accumbens reduced the effect of a 7-day treatment with 10 mg/kg/day desipramine in the forced swimming test. Bilateral injections of 5 or 1 μg sulpiride in the caudate-putamen did not modify the anti-immobility effect of desipramine. The data support the hypothesis that dopamine mechanisms in the limbic regions of the brain of the rat are involved in the effect of repeated treatment with desipramine in the forced swimming test.

Original languageEnglish
Pages (from-to)1469-1472
Number of pages4
JournalNeuropharmacology
Volume26
Issue number10
DOIs
Publication statusPublished - 1987

Keywords

  • caudate-putamen
  • desipramine
  • forced swimming test
  • nucleus accumbens
  • sulpiride

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Fingerprint Dive into the research topics of 'Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test'. Together they form a unique fingerprint.

  • Cite this