Bilateral injections of 5 or 1 (but not 0.5) μg sulpiride into the nucleus accumbens reduced the effect of a 7-day treatment with 10 mg/kg/day desipramine in the forced swimming test. Bilateral injections of 5 or 1 μg sulpiride in the caudate-putamen did not modify the anti-immobility effect of desipramine. The data support the hypothesis that dopamine mechanisms in the limbic regions of the brain of the rat are involved in the effect of repeated treatment with desipramine in the forced swimming test.
- forced swimming test
- nucleus accumbens
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery