Abstract
(+)-Fenfluramine, a 5-hydroxytryptamine (5-HT) releaser and uptake blocker, m-chlorophenylpiperazine (CPP), a 5-HT receptor agonist, and clonidine, an agonist at adrenoceptors, were studied for their ability to modify jumping and wet dog shakes in morphine abstinent rats. (+)-Fenfluramine and CPP blocked jumping with no effect on wet dog shakes whereas the reverse was true for clonidine. The results further show that 5-HT mechanisms are preferentially involved in the expression of jumping in morphine-abstinent rats.
| Original language | English |
|---|---|
| Pages (from-to) | 68-70 |
| Number of pages | 3 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 36 |
| Issue number | 1 |
| Publication status | Published - 1984 |
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
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Romandini, S., Cervo, L., & Samanin, R. (1984). Evidence that drugs increasing 5-hydroxytryptamine transmission block jumping but not wet dog shakes in morphine abstinent rats: A comparison with clonidine. Journal of Pharmacy and Pharmacology, 36(1), 68-70.