Evidence that drugs increasing 5-hydroxytryptamine transmission block jumping but not wet dog shakes in morphine abstinent rats: A comparison with clonidine

S. Romandini, L. Cervo, R. Samanin

Research output: Contribution to journalArticle

Abstract

(+)-Fenfluramine, a 5-hydroxytryptamine (5-HT) releaser and uptake blocker, m-chlorophenylpiperazine (CPP), a 5-HT receptor agonist, and clonidine, an agonist at adrenoceptors, were studied for their ability to modify jumping and wet dog shakes in morphine abstinent rats. (+)-Fenfluramine and CPP blocked jumping with no effect on wet dog shakes whereas the reverse was true for clonidine. The results further show that 5-HT mechanisms are preferentially involved in the expression of jumping in morphine-abstinent rats.

Original languageEnglish
Pages (from-to)68-70
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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