Abstract
1. 1. Recent pharmacological and biochemical data on the role of brain serotonin in the anorectic activity of some drugs are discussed. 2. 2. Quipazine and meta-chlorophenylpiperazine, two displacers of serotonin binding to brain membranes, caused powerful anorexia in rats. This effect was prevented by methergoline, a central serotonin antagonist, but not by various procedures known to interfere with brain catecholamines. 3. 3. LM 5008, a potent and specific inhibitor of serotonin neuronal uptake, did not significantly change food intake. Since, unlike fenfluramine, this compound does not markedly increase serotonin release nor does it act as an agonist at postsynaptic receptors, as quipazine and metachlorophenylpiperazine do, it is suggested that increased serotonin release and/or direct stimulation of postsynaptic receptors play a more important role than upake inhibition in the anorexia induced by drugs acting on brain serotonin.
| Original language | English |
|---|---|
| Pages (from-to) | 363-369 |
| Number of pages | 7 |
| Journal | Progress in Neuro-Psychopharmacology |
| Volume | 4 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - 1980 |
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Keywords
- anorectic drugs
- food intake
- serotonin receptors
- serotonin release
- serotonin uptake
ASJC Scopus subject areas
- Pharmacology (medical)
- Psychiatry and Mental health
- Neuroscience(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Medicine(all)
Cite this
Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain. / Samanin, Rosario; Mennini, Tiziana; Garattini, Silvio.
In: Progress in Neuro-Psychopharmacology, Vol. 4, No. 4-5, 1980, p. 363-369.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain
AU - Samanin, Rosario
AU - Mennini, Tiziana
AU - Garattini, Silvio
PY - 1980
Y1 - 1980
N2 - 1. 1. Recent pharmacological and biochemical data on the role of brain serotonin in the anorectic activity of some drugs are discussed. 2. 2. Quipazine and meta-chlorophenylpiperazine, two displacers of serotonin binding to brain membranes, caused powerful anorexia in rats. This effect was prevented by methergoline, a central serotonin antagonist, but not by various procedures known to interfere with brain catecholamines. 3. 3. LM 5008, a potent and specific inhibitor of serotonin neuronal uptake, did not significantly change food intake. Since, unlike fenfluramine, this compound does not markedly increase serotonin release nor does it act as an agonist at postsynaptic receptors, as quipazine and metachlorophenylpiperazine do, it is suggested that increased serotonin release and/or direct stimulation of postsynaptic receptors play a more important role than upake inhibition in the anorexia induced by drugs acting on brain serotonin.
AB - 1. 1. Recent pharmacological and biochemical data on the role of brain serotonin in the anorectic activity of some drugs are discussed. 2. 2. Quipazine and meta-chlorophenylpiperazine, two displacers of serotonin binding to brain membranes, caused powerful anorexia in rats. This effect was prevented by methergoline, a central serotonin antagonist, but not by various procedures known to interfere with brain catecholamines. 3. 3. LM 5008, a potent and specific inhibitor of serotonin neuronal uptake, did not significantly change food intake. Since, unlike fenfluramine, this compound does not markedly increase serotonin release nor does it act as an agonist at postsynaptic receptors, as quipazine and metachlorophenylpiperazine do, it is suggested that increased serotonin release and/or direct stimulation of postsynaptic receptors play a more important role than upake inhibition in the anorexia induced by drugs acting on brain serotonin.
KW - anorectic drugs
KW - food intake
KW - serotonin receptors
KW - serotonin release
KW - serotonin uptake
UR - http://www.scopus.com/inward/record.url?scp=0019297744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019297744&partnerID=8YFLogxK
U2 - 10.1016/0364-7722(80)90006-5
DO - 10.1016/0364-7722(80)90006-5
M3 - Article
VL - 4
SP - 363
EP - 369
JO - Progress in Neuro-Psychopharmacology
JF - Progress in Neuro-Psychopharmacology
SN - 0364-7722
IS - 4-5
ER -