Evidence that nebulin is a protein-ruler in muscle thin filaments

S. Labeit, T. Gibson, A. Lakey, K. Leonard, M. Zeviani, P. Knight, J. Wardale, J. Trinick

Research output: Contribution to journalArticlepeer-review


Partial amino acid sequence was obtained from the massive myofibrillar protein nebulin. This consists of repeating motifs of about 35 residues and super-repeats of 7 × 35 = 245 residues. The repeat-motifs are likely to be largely α-helical and to interact with both actin and tropomyosin in thin filaments. Nebulin from different species was found to vary in size in proportion to filament length. The data are consistent with the proposal that nebulin acts as a protein-ruler to regulate precise thin filament assembly.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalFEBS Letters
Issue number2
Publication statusPublished - May 6 1991


  • Nebulin
  • Protein-ruler
  • Striated muscle
  • Thin filament

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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