Evoked potential study in facio-scapulo-humeral muscular dystrophy

B. Fierro, O. Daniele, A. Aloisio, D. Buffa, V. La Bua, M. Oliveri, L. Manfrè, F. Brighina

Research output: Contribution to journalArticlepeer-review


Nerve conduction velocities (NCVs), somatosensory (SEPs) and auditory evoked potentials (BAEPs) were recorded in 9 patients with facio-scapulo- humeral dystrophy (FSHD) and in 20 age-matched controls. In FSHD patients a significant increase of the nerve distal sensory latencies and of the absolute SEP latencies revealed a subclinical involvement of the afferent sensory pathways, as well as the abnormal slowing of the later components of the BAEPs, pointed to a central auditory dysfunction. Moreover all patients underwent brain MRI that showed the presence of white matter hyperintense lesions in 4 of them (44%). No correlations were found between individual or total number of SEP and BAEP abnormal electrophysiological parameters and severity of WMHL, age, age at onset, duration of the disease or muscular impairment. These findings make the interpretation and pathophysiology of the nervous damage in FSHD rather uncertain. More studies are required to better define the aspects of neurogenic involvement in this type of muscular dystrophy.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalActa Neurologica Scandinavica
Issue number6
Publication statusPublished - 1997


  • Evoked potentials
  • MRI, muscular dystrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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