Evolution in the treatment of gastroenteropancreatic-neuroendocrine neoplasms, focus on systemic therapeutic options: A systematic review

Sara Pusceddu, Filippo De Braud, Fabrizio Festinese, Cristina Bregant, Alice Lorenzoni, Marco Maccauro, Massimo Milione, Laura Concas, Barbara Formisano, Livia Leuzzi, Vincenzo Mazzaferro, Roberto Buzzoni

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors. The present review discusses current therapeutic strategies for the treatment of gastro-entero-pancreatic NEN. Several systemic options are currently available, including medical systemic chemotherapy, biological drugs, somatostatin analogs and peptide receptor radionuclide therapy. The carcinoid syndrome can be adequately controlled with somatostatin analogs; chemotherapy has shown positive outcomes in poor prognosis patients, and peptide receptor radionuclide therapy is a promising treatment based on the use of radioisotopes for advanced disease expressing somatostatin receptors. Targeted therapies, such as multikinase inhibitors and monoclonal antibodies are also recommended or under evaluation for the treatment of advanced NENs, but some critical issues in clinical practice remain unresolved. Depending upon the development of the disease, a multimodal approach is recommended. The treatment strategy for metastatic patients should be planned by a multidisciplinary team in order to define the optimal sequence of treatments.

Original languageEnglish
Pages (from-to)1947-1959
Number of pages13
JournalFuture Oncology
Volume11
Issue number13
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • chemotherapy
  • neuroendocrine tumor
  • PRRT
  • somatostatin analogs
  • target therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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