Evolution of antiretroviral prescription and response over a period of 8 years: An Italian multicentre observational prospective cohort study

L. Sighinolfi, C. Torti, C. Zeni, F. Ghinelli, F. Suter, F. Maggiolo, A. Antinori, G. Antonucci, F. Castelnuovo, N. Ladisa, M. Migliorino, S. Novati, A. De Luca, S. Lo Caputo, G. Paraninfo, C. Tinelli, G. Carosi, G. Carosi, C. Torti, M. PuotiE. Quiros-Roldan, A. Antinori, F. Antonucci, R. Cauda, A. De Luca, G. Angarano, A. Saracino, A. D'Arminio, P. Cicconi, F. Mazzotta, S. Lo Caputo, N. Marino, L. Minoli, R. Maserati, C. Tinelli, F. Ghinelli, L. Sighinolfi, G. Pastore, N. Ladisa, T. Quirino, M. Migliorino, F. Suter, F. Maggiolo

Research output: Contribution to journalArticlepeer-review

Abstract

There is very less information on the use of antiretroviral (ARV) drugs and viro-immunological outcome over calendar years in Italy. We performed an analysis of a prospective observational cohort (MASTER) to assess antiretroviral drug use in first line HAART and explore whether initial treatment response changed over the years. 3,648 ARV-naive patients with available HIV-RNA and CD4+ T cell count at baseline who started their first HAART between 1997 and 2004 were studied. Mean age was 37.7 years; they were mostly males (72.3%) and Italians (81.4%). Prescription of non-nucleoside reverse transcriptase inhibitors and protease inhibitors boosted with ritonavir rose from 0.3% in 1997 to 58% in 2004 and from 0.3%in 1997 to 33.4% in 2004, respectively. Virological failures decreased over calendar years: from 42.9% in 1997 to 8.1%in 2004 after 6 months of HAART (p <0.001); from 42.1%(1997) to 10.7% (2004) after 12 months (p <0.001) and; from 39.5% (1997) to 8.2% (2004) after 18 months (p <0.001). The same trend, but less striking, was found for immunological failure rates. In the general Italian population of HIV-positive patients, evolution of treatment prescription correlated with improved viro-immunological outcome.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalInfection
Volume36
Issue number3
DOIs
Publication statusPublished - Jun 2008

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

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