Evolution of cardiac involvement in progressive ophthalmoplegia with deleted mitochondrial DNA

P. Melacini, C. Angelini, G. Buja, G. Micaglio, M. L. Valente

Research output: Contribution to journalArticle

Abstract

A 43-year-old woman with progressive external ophthalmoplegia developed a bifascicular block and dilatation of the right ventricle during 4 years of follow-up. Histochemical and electron microscopy studies detected mitochondrial abnormalities in ocular, skeletal muscle and cardiac biopsies. This case registers disease progression from the external ocular to the skeletal and cardiac muscles. Mitochondrial DNA was deleted in relation to the morphological abnormality.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalJapanese Heart Journal
Volume31
Issue number1
Publication statusPublished - 1990

Keywords

  • cardiac biopsy
  • external ophthalmoplegia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Evolution of cardiac involvement in progressive ophthalmoplegia with deleted mitochondrial DNA'. Together they form a unique fingerprint.

  • Cite this

    Melacini, P., Angelini, C., Buja, G., Micaglio, G., & Valente, M. L. (1990). Evolution of cardiac involvement in progressive ophthalmoplegia with deleted mitochondrial DNA. Japanese Heart Journal, 31(1), 115-120.