Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years: A case-control study

D. Horakova, J. L. Cox, E. Havrdova, S. Hussein, O. Dolezal, D. Cookfair, M. G. Dwyer, Z. Seidl, N. Bergsland, M. Vaneckova, Robert Zivadinov

Research output: Contribution to journalArticle

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Abstract

Background: There is growing evidence for the concept of multiple sclerosis (MS) as an inflammatory neurode-generative disease, with a different pattern of atrophy evolution in grey matter (GM) and white matter (WM) tissue compartments. Objective: We aimed to investigate the evolution of different MRI measures in early relapsing-remitting patients with MS and in normal controls (NCs) over 2 years. We also evaluated the progression of these MRI measures in a subset of patients who were followed for up to 5 years. Methods: Included in this study were 147 patients who participated in the combination ASA (Avonex Steroids Azathioprine) study and completed full treatment, clinical and MRI assessment at 0,12 and 24 months. A subgroup of 66 patients was followed for 36 months, 51 patients for 48 months and 43 patients for 60 months. Mean age at baseline was 30.7 years, mean disease duration was 5.5 years, mean EDSS was 1.8 and mean annualised relapse rate before study entry was 1.7. MRI scans were performed on a 1.5T scanner every 2 months for the first 2 years and thereafter once yearly for up to 5 years. In addition to the MS group, 27 NCs were examined at months 0, 12 and 24 using the same MRI protocol. Percentage brain volume change (PBVC), GM volume (GMV), WM volume (WMV) and peripheral grey volume (PGV) were measured annually using SIENA/X software. T2-hyperintense lesion volume (LV), lateral ventricle volume (LW) and third ventricle width (3VW) were also assessed annually. Results: Over the period of 0-24 months, patients with MS lost significantly more GMV (-2.6% vs -0.72%, p

Original languageEnglish
Pages (from-to)407-414
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume79
Issue number4
DOIs
Publication statusPublished - Apr 2008

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Relapsing-Remitting Multiple Sclerosis
Case-Control Studies
Multiple Sclerosis
Third Ventricle
Lateral Ventricles
Azathioprine
Atrophy
Software
Steroids
Magnetic Resonance Imaging
Recurrence
Brain

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years : A case-control study. / Horakova, D.; Cox, J. L.; Havrdova, E.; Hussein, S.; Dolezal, O.; Cookfair, D.; Dwyer, M. G.; Seidl, Z.; Bergsland, N.; Vaneckova, M.; Zivadinov, Robert.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 79, No. 4, 04.2008, p. 407-414.

Research output: Contribution to journalArticle

Horakova, D, Cox, JL, Havrdova, E, Hussein, S, Dolezal, O, Cookfair, D, Dwyer, MG, Seidl, Z, Bergsland, N, Vaneckova, M & Zivadinov, R 2008, 'Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years: A case-control study', Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, no. 4, pp. 407-414. https://doi.org/10.1136/jnnp.2007.120378
Horakova, D. ; Cox, J. L. ; Havrdova, E. ; Hussein, S. ; Dolezal, O. ; Cookfair, D. ; Dwyer, M. G. ; Seidl, Z. ; Bergsland, N. ; Vaneckova, M. ; Zivadinov, Robert. / Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years : A case-control study. In: Journal of Neurology, Neurosurgery and Psychiatry. 2008 ; Vol. 79, No. 4. pp. 407-414.
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AU - Horakova, D.

AU - Cox, J. L.

AU - Havrdova, E.

AU - Hussein, S.

AU - Dolezal, O.

AU - Cookfair, D.

AU - Dwyer, M. G.

AU - Seidl, Z.

AU - Bergsland, N.

AU - Vaneckova, M.

AU - Zivadinov, Robert

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N2 - Background: There is growing evidence for the concept of multiple sclerosis (MS) as an inflammatory neurode-generative disease, with a different pattern of atrophy evolution in grey matter (GM) and white matter (WM) tissue compartments. Objective: We aimed to investigate the evolution of different MRI measures in early relapsing-remitting patients with MS and in normal controls (NCs) over 2 years. We also evaluated the progression of these MRI measures in a subset of patients who were followed for up to 5 years. Methods: Included in this study were 147 patients who participated in the combination ASA (Avonex Steroids Azathioprine) study and completed full treatment, clinical and MRI assessment at 0,12 and 24 months. A subgroup of 66 patients was followed for 36 months, 51 patients for 48 months and 43 patients for 60 months. Mean age at baseline was 30.7 years, mean disease duration was 5.5 years, mean EDSS was 1.8 and mean annualised relapse rate before study entry was 1.7. MRI scans were performed on a 1.5T scanner every 2 months for the first 2 years and thereafter once yearly for up to 5 years. In addition to the MS group, 27 NCs were examined at months 0, 12 and 24 using the same MRI protocol. Percentage brain volume change (PBVC), GM volume (GMV), WM volume (WMV) and peripheral grey volume (PGV) were measured annually using SIENA/X software. T2-hyperintense lesion volume (LV), lateral ventricle volume (LW) and third ventricle width (3VW) were also assessed annually. Results: Over the period of 0-24 months, patients with MS lost significantly more GMV (-2.6% vs -0.72%, p

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