TY - JOUR
T1 - Evolution of emphysema in relation to smoking
AU - Bellomi, Massimo
AU - Rampinelli, Cristiano
AU - Veronesi, Giulia
AU - Harari, Sergio
AU - Lanfranchi, Federica
AU - Raimondi, Sara
AU - Maisonneuve, Patrick
PY - 2010/2
Y1 - 2010/2
N2 - Purpose: We have little knowledge about the evolution of emphysema, and relatively little is understood about its evolution in relation to smoking habits. This study aims to assess the evolution of emphysema in asymptomatic current and former smokers over2 years and to investigate the association with subjects' characteristics. The study was approvedbyour Ethics Committee and all participants provided written informed consent. Materials and methods: We measured emphysema by automatic low-dose computed tomography densitometry in 254 current and 282 former smokers enrolled in a lung-cancer screening. The measures were repeated after 2 years. The association between subjects' characteristics, smoking habits and emphysema were assessed by chi-squared and Wilcoxon tests. Univariate and multivariate odds ratios (OR) with 95% confidence intervals (CI) were calculated for the risk of emphysema worsening according to subjects' characteristics. We assessed the trend of increasing risk of emphysema progression by smoking habits using the Mantel-Haenszel chi-squared test. Results: The median percentage increase in emphysema over a 2-year period was significantly higher in current than in former smokers (OR 1.8; 95% CI 1.3-2.6; p
AB - Purpose: We have little knowledge about the evolution of emphysema, and relatively little is understood about its evolution in relation to smoking habits. This study aims to assess the evolution of emphysema in asymptomatic current and former smokers over2 years and to investigate the association with subjects' characteristics. The study was approvedbyour Ethics Committee and all participants provided written informed consent. Materials and methods: We measured emphysema by automatic low-dose computed tomography densitometry in 254 current and 282 former smokers enrolled in a lung-cancer screening. The measures were repeated after 2 years. The association between subjects' characteristics, smoking habits and emphysema were assessed by chi-squared and Wilcoxon tests. Univariate and multivariate odds ratios (OR) with 95% confidence intervals (CI) were calculated for the risk of emphysema worsening according to subjects' characteristics. We assessed the trend of increasing risk of emphysema progression by smoking habits using the Mantel-Haenszel chi-squared test. Results: The median percentage increase in emphysema over a 2-year period was significantly higher in current than in former smokers (OR 1.8; 95% CI 1.3-2.6; p
KW - Computed tomography
KW - Densitometry
KW - Lung cancer screening
KW - Pulmonary emphysema
KW - Smoking-related disease
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U2 - 10.1007/s00330-009-1548-6
DO - 10.1007/s00330-009-1548-6
M3 - Article
C2 - 19705126
AN - SCOPUS:77951247079
VL - 20
SP - 286
EP - 292
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 2
ER -