Evolution of fungemia in an Italian region

A. Prigitano, C. Cavanna, M. Passera, M. Gelmi, E. Sala, C. Ossi, A. Grancini, M. Calabrò, S. Bramati, M. Tejada, F. Lallitto, C. Farina, V. Rognoni, M. A. Fasano, B. Pini, L. Romanò, M. Cogliati, M. C. Esposto, A. M. Tortorano

Research output: Contribution to journalArticle

Abstract

Background: Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy. Methods: Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed. Results: A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins < 2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC. Conclusions: No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.

Original languageEnglish
Article number100906
JournalJournal de Mycologie Medicale
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Fungemia
Echinocandins
Fungi
Saccharomyces cerevisiae
Exophiala
Rhodotorula
Azoles
Cryptococcus neoformans
Fluconazole
Fusarium
Amphotericin B
Infection
Candida
Italy
Public Health
Therapeutics

Keywords

  • Antifungal resistance
  • Candida
  • Candidaemia
  • Epidemiology
  • Fungemia

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Prigitano, A., Cavanna, C., Passera, M., Gelmi, M., Sala, E., Ossi, C., ... Tortorano, A. M. (Accepted/In press). Evolution of fungemia in an Italian region. Journal de Mycologie Medicale, [100906]. https://doi.org/10.1016/j.mycmed.2019.100906

Evolution of fungemia in an Italian region. / Prigitano, A.; Cavanna, C.; Passera, M.; Gelmi, M.; Sala, E.; Ossi, C.; Grancini, A.; Calabrò, M.; Bramati, S.; Tejada, M.; Lallitto, F.; Farina, C.; Rognoni, V.; Fasano, M. A.; Pini, B.; Romanò, L.; Cogliati, M.; Esposto, M. C.; Tortorano, A. M.

In: Journal de Mycologie Medicale, 01.01.2019.

Research output: Contribution to journalArticle

Prigitano, A, Cavanna, C, Passera, M, Gelmi, M, Sala, E, Ossi, C, Grancini, A, Calabrò, M, Bramati, S, Tejada, M, Lallitto, F, Farina, C, Rognoni, V, Fasano, MA, Pini, B, Romanò, L, Cogliati, M, Esposto, MC & Tortorano, AM 2019, 'Evolution of fungemia in an Italian region', Journal de Mycologie Medicale. https://doi.org/10.1016/j.mycmed.2019.100906
Prigitano, A. ; Cavanna, C. ; Passera, M. ; Gelmi, M. ; Sala, E. ; Ossi, C. ; Grancini, A. ; Calabrò, M. ; Bramati, S. ; Tejada, M. ; Lallitto, F. ; Farina, C. ; Rognoni, V. ; Fasano, M. A. ; Pini, B. ; Romanò, L. ; Cogliati, M. ; Esposto, M. C. ; Tortorano, A. M. / Evolution of fungemia in an Italian region. In: Journal de Mycologie Medicale. 2019.
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abstract = "Background: Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy. Methods: Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed. Results: A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52{\%}), followed by C. parapsilosis (15{\%}) and C glabrata (13{\%}). As in the previous surveys the antifungal resistance is rare (echinocandins < 2{\%}, fluconazole 6{\%}, amphotericin B 0.6{\%}). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC. Conclusions: No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.",
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AU - Passera, M.

AU - Gelmi, M.

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AU - Grancini, A.

AU - Calabrò, M.

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AU - Farina, C.

AU - Rognoni, V.

AU - Fasano, M. A.

AU - Pini, B.

AU - Romanò, L.

AU - Cogliati, M.

AU - Esposto, M. C.

AU - Tortorano, A. M.

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N2 - Background: Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy. Methods: Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed. Results: A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins < 2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC. Conclusions: No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.

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