Evolution of long-term outcome of liver resection for colorectal metastases: Analysis of actual 5-year survival rates over two decades

Luca Viganò, Nadia Russolillo, Alessandro Ferrero, Serena Langella, Elisa Sperti, Lorenzo Capussotti

Research output: Contribution to journalArticle


Background. Liver resection (LR) is the only potentially curative treatment of colorectal liver metastases (CRLM). Its outcome over the past 2 decades was studied using actual 5-year survival rates. Methods. Data of 393 consecutive patients who underwent LR for CRLM at Mauriziano Umberto I (Turin) until June 2005 were analyzed. Excluding R2 resections (n = 4) or incomplete 5-year follow-up (n = 13), 376 patients were divided according to LR date into groups A (before 1995: 90 patients), B (1995-2000: 94 patients), C (2001-2005: 192). Results. Group C presented increased multiple and bilobar metastases compared with combined groupAandB(C vsAB: 54.7% vs 40.2%, P = 0.005; 28.1% vs 19.0%, P = 0.038, respectively), decreased metastases diameter (C vs AB: 32 vs 40 mm, P = 0.0001). The 5-year overall survival, calculated excluding 4 operative mortalities (group AB), increased over the years (A, 20.5%; B, 32.6%; C, 46.4%; P

Original languageEnglish
Pages (from-to)2035-2044
Number of pages10
JournalAnnals of Surgical Oncology
Issue number6
Publication statusPublished - Jun 2012


ASJC Scopus subject areas

  • Surgery
  • Oncology

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