Abstract

Objectives: The management of HIV disease is complicated by the incidence of a new spectrum of comorbid noncommunicable diseases (NCDs). It is important to document changes in the prevalence of NCDs over time. The aim of the study was to describe the impact of ageing on HIV markers and on the prevalence of NCDs in people living with HIV (PLWHIV) in the Italian Cohort of Individuals, Naïve for Antiretrovirals (ICONA) seen for care in 2004–2014. Methods: Analyses were conducted separately for a closed cohort (same people seen at both times) and an open cohort (all people under follow-up). We used the χ2 test for categorical factors and the Wilcoxon test for quantitative factors to compare profiles over time. Results: The closed cohort included 1517 participants and the open cohort 3668 under follow-up in 2004 and 6679 in 2014. The median age of the open cohort was 41 [interquartile range (IQR) 37–46] years in 2004 and 44 (IQR 36–52) years in 2014. Analysis of the closed cohort showed an increase in the prevalence of some NCDs [the prevalence of dyslipidaemia increased from 75% in 2004 to 91% in 2014, that of hypertension from 67 to 84%, and that of cardiovascular disease (CVD) from 18 to 32%] and a decrease in renal function (5% with eGFR < 60 mL/min per 1.73 m2 in 2004 versus 30% in 2014); the percentage of people in the high-risk group for the Framingham CHD score more than tripled (from 13 to 45%). Results in the open cohort were similar. Conclusions: The burden of NCDs in our PLWHIV population markedly worsened over a 10-year time-span, which is likely to be a result of the effects of both ageing and HIV infection as well as their interaction. Special attention must be given to the management and prevention of NCDs.

Original languageEnglish
JournalHIV Medicine
DOIs
Publication statusE-pub ahead of print - Nov 21 2018

Fingerprint

Comorbidity
Cohort Studies
HIV
Disease Management
Dyslipidemias
HIV Infections
Cardiovascular Diseases
Hypertension
Kidney
Incidence
Population

Keywords

  • noncommunicable diseases (NCDs)
  • persons living with HIV (PLWHIV)
  • time trend

ASJC Scopus subject areas

  • Health Policy
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

@article{6fde20cc3c154ada803a3125a9d25993,
title = "Evolution of major non-HIV-related comorbidities in HIV-infected patients in the Italian Cohort of Individuals, Na{\"i}ve for Antiretrovirals (ICONA) Foundation Study cohort in the period 2004–2014",
abstract = "Objectives: The management of HIV disease is complicated by the incidence of a new spectrum of comorbid noncommunicable diseases (NCDs). It is important to document changes in the prevalence of NCDs over time. The aim of the study was to describe the impact of ageing on HIV markers and on the prevalence of NCDs in people living with HIV (PLWHIV) in the Italian Cohort of Individuals, Na{\"i}ve for Antiretrovirals (ICONA) seen for care in 2004–2014. Methods: Analyses were conducted separately for a closed cohort (same people seen at both times) and an open cohort (all people under follow-up). We used the χ2 test for categorical factors and the Wilcoxon test for quantitative factors to compare profiles over time. Results: The closed cohort included 1517 participants and the open cohort 3668 under follow-up in 2004 and 6679 in 2014. The median age of the open cohort was 41 [interquartile range (IQR) 37–46] years in 2004 and 44 (IQR 36–52) years in 2014. Analysis of the closed cohort showed an increase in the prevalence of some NCDs [the prevalence of dyslipidaemia increased from 75{\%} in 2004 to 91{\%} in 2014, that of hypertension from 67 to 84{\%}, and that of cardiovascular disease (CVD) from 18 to 32{\%}] and a decrease in renal function (5{\%} with eGFR < 60 mL/min per 1.73 m2 in 2004 versus 30{\%} in 2014); the percentage of people in the high-risk group for the Framingham CHD score more than tripled (from 13 to 45{\%}). Results in the open cohort were similar. Conclusions: The burden of NCDs in our PLWHIV population markedly worsened over a 10-year time-span, which is likely to be a result of the effects of both ageing and HIV infection as well as their interaction. Special attention must be given to the management and prevention of NCDs.",
keywords = "noncommunicable diseases (NCDs), persons living with HIV (PLWHIV), time trend",
author = "{d'Arminio Monforte}, A. and H. Diaz-Cuervo and {De Luca}, A. and F. Maggiolo and A. Cingolani and S. Bonora and A. Castagna and E. Girardi and A. Antinori and {Lo Caputo}, S. and G. Guaraldi and A. Cozzi-Lepri and {the ICONA Foundation Study Group} and F. Castelli and M. Galli and G. Ippolito and A. Lazzarin and Perno, {C. F.} and G. Rezza and A. Ammassari and A. Calcagno and A. Cingolani and P. Cinque and N. Gianotti and A. Gori and S. Nozza and Santoro, {M. M.} and Santoro, {M. M.} and M. Zaccarelli and L. Galli and P. Lorenzini and A. Rodano' and F. Carletti and S. Carrara and {Di Caro}, A. and S. Graziano and G. Prota and S. Quartu and S. Truffa and V. Donati and C. Viscoli and A. Gori and V. Esposito and F. Sozio and G. Magnani and A. Cristaudo and R. Acinapura and M. Capozzi and S. Cicalini and Plazzi, {M. M.} and M. Sciandra",
year = "2018",
month = "11",
day = "21",
doi = "10.1111/hiv.12683",
language = "English",
journal = "HIV Medicine",
issn = "1464-2662",
publisher = "Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Evolution of major non-HIV-related comorbidities in HIV-infected patients in the Italian Cohort of Individuals, Naïve for Antiretrovirals (ICONA) Foundation Study cohort in the period 2004–2014

AU - d'Arminio Monforte, A.

AU - Diaz-Cuervo, H.

AU - De Luca, A.

AU - Maggiolo, F.

AU - Cingolani, A.

AU - Bonora, S.

AU - Castagna, A.

AU - Girardi, E.

AU - Antinori, A.

AU - Lo Caputo, S.

AU - Guaraldi, G.

AU - Cozzi-Lepri, A.

AU - the ICONA Foundation Study Group

AU - Castelli, F.

AU - Galli, M.

AU - Ippolito, G.

AU - Lazzarin, A.

AU - Perno, C. F.

AU - Rezza, G.

AU - Ammassari, A.

AU - Calcagno, A.

AU - Cingolani, A.

AU - Cinque, P.

AU - Gianotti, N.

AU - Gori, A.

AU - Nozza, S.

AU - Santoro, M. M.

AU - Santoro, M. M.

AU - Zaccarelli, M.

AU - Galli, L.

AU - Lorenzini, P.

AU - Rodano', A.

AU - Carletti, F.

AU - Carrara, S.

AU - Di Caro, A.

AU - Graziano, S.

AU - Prota, G.

AU - Quartu, S.

AU - Truffa, S.

AU - Donati, V.

AU - Viscoli, C.

AU - Gori, A.

AU - Esposito, V.

AU - Sozio, F.

AU - Magnani, G.

AU - Cristaudo, A.

AU - Acinapura, R.

AU - Capozzi, M.

AU - Cicalini, S.

AU - Plazzi, M. M.

AU - Sciandra, M.

PY - 2018/11/21

Y1 - 2018/11/21

N2 - Objectives: The management of HIV disease is complicated by the incidence of a new spectrum of comorbid noncommunicable diseases (NCDs). It is important to document changes in the prevalence of NCDs over time. The aim of the study was to describe the impact of ageing on HIV markers and on the prevalence of NCDs in people living with HIV (PLWHIV) in the Italian Cohort of Individuals, Naïve for Antiretrovirals (ICONA) seen for care in 2004–2014. Methods: Analyses were conducted separately for a closed cohort (same people seen at both times) and an open cohort (all people under follow-up). We used the χ2 test for categorical factors and the Wilcoxon test for quantitative factors to compare profiles over time. Results: The closed cohort included 1517 participants and the open cohort 3668 under follow-up in 2004 and 6679 in 2014. The median age of the open cohort was 41 [interquartile range (IQR) 37–46] years in 2004 and 44 (IQR 36–52) years in 2014. Analysis of the closed cohort showed an increase in the prevalence of some NCDs [the prevalence of dyslipidaemia increased from 75% in 2004 to 91% in 2014, that of hypertension from 67 to 84%, and that of cardiovascular disease (CVD) from 18 to 32%] and a decrease in renal function (5% with eGFR < 60 mL/min per 1.73 m2 in 2004 versus 30% in 2014); the percentage of people in the high-risk group for the Framingham CHD score more than tripled (from 13 to 45%). Results in the open cohort were similar. Conclusions: The burden of NCDs in our PLWHIV population markedly worsened over a 10-year time-span, which is likely to be a result of the effects of both ageing and HIV infection as well as their interaction. Special attention must be given to the management and prevention of NCDs.

AB - Objectives: The management of HIV disease is complicated by the incidence of a new spectrum of comorbid noncommunicable diseases (NCDs). It is important to document changes in the prevalence of NCDs over time. The aim of the study was to describe the impact of ageing on HIV markers and on the prevalence of NCDs in people living with HIV (PLWHIV) in the Italian Cohort of Individuals, Naïve for Antiretrovirals (ICONA) seen for care in 2004–2014. Methods: Analyses were conducted separately for a closed cohort (same people seen at both times) and an open cohort (all people under follow-up). We used the χ2 test for categorical factors and the Wilcoxon test for quantitative factors to compare profiles over time. Results: The closed cohort included 1517 participants and the open cohort 3668 under follow-up in 2004 and 6679 in 2014. The median age of the open cohort was 41 [interquartile range (IQR) 37–46] years in 2004 and 44 (IQR 36–52) years in 2014. Analysis of the closed cohort showed an increase in the prevalence of some NCDs [the prevalence of dyslipidaemia increased from 75% in 2004 to 91% in 2014, that of hypertension from 67 to 84%, and that of cardiovascular disease (CVD) from 18 to 32%] and a decrease in renal function (5% with eGFR < 60 mL/min per 1.73 m2 in 2004 versus 30% in 2014); the percentage of people in the high-risk group for the Framingham CHD score more than tripled (from 13 to 45%). Results in the open cohort were similar. Conclusions: The burden of NCDs in our PLWHIV population markedly worsened over a 10-year time-span, which is likely to be a result of the effects of both ageing and HIV infection as well as their interaction. Special attention must be given to the management and prevention of NCDs.

KW - noncommunicable diseases (NCDs)

KW - persons living with HIV (PLWHIV)

KW - time trend

UR - http://www.scopus.com/inward/record.url?scp=85056855361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056855361&partnerID=8YFLogxK

U2 - 10.1111/hiv.12683

DO - 10.1111/hiv.12683

M3 - Article

JO - HIV Medicine

JF - HIV Medicine

SN - 1464-2662

ER -