Evolution of Neurologic Features in Williams Syndrome

Chiara Gagliardi, Sara Martelli, Michael D. Burt, Renato Borgatti

Research output: Contribution to journalArticle

Abstract

As a part of a large multidisciplinary clinical and research follow-up study, 47 Williams syndrome patients underwent detailed neurologic testing. Because previous studies have documented the absence of major neurologic signs in Williams syndrome, the neurologic testing focused on soft signs. Previous findings of impairment of both gross and fine motor coordination were confirmed, and the presence of mild cerebellar and extrapyramidal signs was documented. In a 4-year follow-up study, an age-related pattern was revealed: soft extrapyramidal signs became more evident from 8 years of age and increased in the 14+ age group. The results are discussed according to a hypothesis related to the dopaminergic system involvement in Williams syndrome: anomalous organization or accelerated ageing process.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalPediatric Neurology
Volume36
Issue number5
DOIs
Publication statusPublished - May 2007

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ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

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