Evolution of pancreatectomy with en bloc venous resection for pancreatic cancer in Italy. Retrospective cohort study on 425 cases in 10 pancreatic referral units

Giuseppe Nigri, Niccolò Petrucciani, Antonio Daniele Pinna, Matteo Ravaioli, Elio Jovine, Francesco Minni, Gian Luca Grazi, Piero Chirletti, Gianpaolo Balzano, Fabio Ferla, Luciano De Carlis, Giuseppe Tisone, Niccolò Napoli, Ugo Boggi, Giovanni Ramacciato

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The aim of this study is to analyze the evolution of pancreatectomy with venous resection in 10 referral Italian centers in the last 25 years. Methods: A multicenter database of 425 patients submitted to pancreatectomy with venous resection between 1991 and 2015 was retrospectively analyzed. Patients were classified in 5 periods: 1 (1991–1995); 2 (1996–2000); 3 (2001–2005); 4 (2006–2010); 5 (2011–2015). Indications and outcomes were compared according to the period of surgery. Results: Nineteen patients were operated in period 1, 28 in period 2, 91 in period 3, 140 in period 4, and 147 in period 5. Use of neoadjuvant therapy increased from 0% in period 1 and 2–12.1% in period 5. Postoperative complications ranged from 46.3% to 67.8%, and mortality from 5.3% to 9.2%. Median survival progressively increased, from 6 months in period 1–16 months in period 2, 24 months in period 3 and 4 and 35 months in period 5 (p = 0.004). Period, venous and nodal invasion were significant prognostic factors for survival. Conclusion: Management and outcomes of pancreatectomy with venous resection have evolved in the last 25 years in Italy. Improvement in patients’ multidisciplinary management has lead to significant improvement of median survival.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalInternational Journal of Surgery
Volume55
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Italy
  • Pancreatectomy
  • Pancreatic cancer
  • Time frame
  • Venous resection

ASJC Scopus subject areas

  • Surgery

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