Evolution of surgical treatment of cartilaginous lesions

S. Giannini, M. Cavallo, F. Castagnini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Osteochondral lesion (OLT) of the ankle joint is an injury involving the chondral layer and the subchondral bone, usually traumatic in etiology. OLT treatment is debated and no clear guidelines exist. Reparative procedures are effective in small-size lesions, but a fibrocartilage layer with low biomechanical properties is generated. Regenerative techniques, supplying a layer of hyaline cartilage, are welcomed. Open-field autologous chondrocytes implantation (ACI) was the first regenerative technique relying on cells to be adopted, but it was rich in technical drawbacks. Arthroscopic ACI was developed thanks to scaffold introduction and a specific instrumentation. The technique was simplified, and the clinical and MRI results were comparable with open-field ACI. Bone marrow-derived cells transplantation (BMDCT) was then developed to overcome the two-step surgery, the high costs, and the laboratoristic phase. BMDCT is based on autologous mesenchymal stem cells, more useful in case of large bony defects and even degenerated joint environment. The clinical, MRI, and histological outcomes were good at midterm follow-up. Regenerative techniques are reliable procedures: Nevertheless, more biological studies are needed to understand the applicability and the possible improvements of these procedures.

Original languageEnglish
Title of host publicationCartilage Lesions of the Ankle
PublisherSpringer Berlin Heidelberg
Pages17-26
Number of pages10
ISBN (Print)9783662463321, 9783662463314
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Chondrocytes
Bone Marrow Transplantation
Fibrocartilage
Hyaline Cartilage
Ankle Joint
Mesenchymal Stromal Cells
Cartilage
Therapeutics
Joints
Guidelines
Costs and Cost Analysis
Bone and Bones
Wounds and Injuries

Keywords

  • Ankle
  • Bone marrow-derived cells
  • Chondrocytes
  • Osteochondral lesions
  • Regenerative technique

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Giannini, S., Cavallo, M., & Castagnini, F. (2015). Evolution of surgical treatment of cartilaginous lesions. In Cartilage Lesions of the Ankle (pp. 17-26). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46332-1_3

Evolution of surgical treatment of cartilaginous lesions. / Giannini, S.; Cavallo, M.; Castagnini, F.

Cartilage Lesions of the Ankle. Springer Berlin Heidelberg, 2015. p. 17-26.

Research output: Chapter in Book/Report/Conference proceedingChapter

Giannini, S, Cavallo, M & Castagnini, F 2015, Evolution of surgical treatment of cartilaginous lesions. in Cartilage Lesions of the Ankle. Springer Berlin Heidelberg, pp. 17-26. https://doi.org/10.1007/978-3-662-46332-1_3
Giannini S, Cavallo M, Castagnini F. Evolution of surgical treatment of cartilaginous lesions. In Cartilage Lesions of the Ankle. Springer Berlin Heidelberg. 2015. p. 17-26 https://doi.org/10.1007/978-3-662-46332-1_3
Giannini, S. ; Cavallo, M. ; Castagnini, F. / Evolution of surgical treatment of cartilaginous lesions. Cartilage Lesions of the Ankle. Springer Berlin Heidelberg, 2015. pp. 17-26
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