Evolution of the endoplasmic reticulum and the Golgi complex.

Alexander A. Mironov, Victor V. Banin, Irina S. Sesorova, Viacheslav V. Dolgikh, Alberto Luini, Galina V. Beznoussenko

Research output: Contribution to journalArticle

Abstract

By analyzing the morpho-physiological features of the Golgi complex, its relationship with the endoplasmic reticulum in different species, and the molecular machineries involved in intracellular transport, we conclude that; (1) all eukaryotic cells have either Golgi complexes or remnants thereof; (2) all eukaryotic cells have a large minimal set of proteins that are involved in intracellular transport; and (3) several indispensable molecular machines are always present in secreting eukaryotic cells. Using this information, our data about mechanisms of intra-Golgi transport and phylogenetic analysis of several molecular machines, we propose a model for the evolution of the Golgi complex and the endoplasmic reticulum.

Original languageEnglish
Pages (from-to)61-72
Number of pages12
JournalAdvances in Experimental Medicine and Biology
Volume607
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Mironov, A. A., Banin, V. V., Sesorova, I. S., Dolgikh, V. V., Luini, A., & Beznoussenko, G. V. (2007). Evolution of the endoplasmic reticulum and the Golgi complex. Advances in Experimental Medicine and Biology, 607, 61-72.