TY - JOUR
T1 - Evolution of the X-specific block embedded in the human Xq21.3/Yp11.1 homology region
AU - Vacca, Marcella
AU - Matarazzo, Maria Rosaria
AU - Jones, Jonathan
AU - Spalluto, Cosma
AU - Archidiacono, Nicoletta
AU - Ma, Peter
AU - Rocchi, Mariano
AU - D'Urso, Michele
AU - Chen, Ellson Y.
AU - D'Esposito, Maurizio
AU - Mumm, Steven
PY - 1999/12/1
Y1 - 1999/12/1
N2 - The region Xq21.3/Yp11.1 represents the largest segment of homology between the sex chromosomes in humans, though no recombination occurs in male meiosis. It presumably arose as a transposition from the X to the Y chromosome; the present-day organization in the latter chromosome indicates a paracentric inversion that disrupted its continuity. Moreover, an X-specific block (defined by the marker DXS214) is embedded in the region. Previously, no hypotheses about the length, origin, or evolution of this X-specific segment have been proposed. Here we report on the refinement of the size and the sequence of the distal boundary of the X-specific block. Furthermore, we have tracked by FISH experiments the evolution of this region in primates. This further clarifies the multistep mechanism of origin for the XY homology region, by demonstrating that the X-specific block was deleted from the Y chromosome after the initial transfer from the X chromosome.
AB - The region Xq21.3/Yp11.1 represents the largest segment of homology between the sex chromosomes in humans, though no recombination occurs in male meiosis. It presumably arose as a transposition from the X to the Y chromosome; the present-day organization in the latter chromosome indicates a paracentric inversion that disrupted its continuity. Moreover, an X-specific block (defined by the marker DXS214) is embedded in the region. Previously, no hypotheses about the length, origin, or evolution of this X-specific segment have been proposed. Here we report on the refinement of the size and the sequence of the distal boundary of the X-specific block. Furthermore, we have tracked by FISH experiments the evolution of this region in primates. This further clarifies the multistep mechanism of origin for the XY homology region, by demonstrating that the X-specific block was deleted from the Y chromosome after the initial transfer from the X chromosome.
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U2 - 10.1006/geno.1999.5996
DO - 10.1006/geno.1999.5996
M3 - Article
C2 - 10610725
AN - SCOPUS:0033372914
VL - 62
SP - 293
EP - 296
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -