Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism

Maria Cristina Vigone, Silvana Caiulo, Marianna Di Frenna, Stefano Ghirardello, Carlo Corbetta, Fabio Mosca, Giovanna Weber

Research output: Contribution to journalArticle

Abstract

Objective To determine the evolution of congenital hypothyroidism in preterms and the clinical features of permanent forms. Study design We retrospectively evaluated 24 preterm children detected by newborn screening for congenital hypothyroidism: first screening with blood-thyroid stimulating hormone cutoff 10 mU/L and second screening with blood-thyroid stimulating hormone cutoff 5 mU/L. After the age of 2 years, patients with eutopic thyroid had diagnostic reevaluations, including thyroid function testing and thyroid ultrasonography after L-thyroxine therapy withdrawal. Results The first screening identified 21.7% of patients with thyroid stimulating hormone elevation, and the second screening identified 73.9% of patients. One patient (4.4%) was identified with a third screening test; 21 patients had an eutopic thyroid and 3 patients a thyroid dysgenesis. At reevaluation, 5 patients (23.8%) showed permanent hypothyroidism (serum-thyroid stimulating hormone [s-TSH] >10 mU/L) resulting in the need to reintroduce therapy, 5 patients (23.8%) showed persistent hyperthyrotropinemia (s-TSH 5-10 mU/L), and 11 infants (52.4%) transient hypothyroidism (s-TSH

Original languageEnglish
Pages (from-to)1296-1302
Number of pages7
JournalJournal of Pediatrics
Volume164
Issue number6
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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