Evolutionary Characteristics of HIV Type 1 Variants Resistant to Protease Inhibitors in the Absence of Drug-Selective Pressure

Enzo Boeri, Nicola Gianotti, Filippo Canducci, Hamid Hasson, Barbara Giudici, Antonella Castagna, Adriano Lazzarin, Massimo Clementi

Research output: Contribution to journalArticle

Abstract

To understand the evolutionary characteristics of HIV-1 variants resistant to protease inhibitors (PI), the replicating plasma virus was analyzed in three patients shifted to a PI-sparing regimen after virological failure. The dynamic features of carryover of mutations associated with PI resistance in the absence of selective pressure on the protease gene indicate that viral variants resistant to reverse transcriptase inhibitors and bearing mutations of the protease sequence can maintain efficient replication capacity in vivo.

Original languageEnglish
Pages (from-to)1151-1153
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2003

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ASJC Scopus subject areas

  • Immunology
  • Virology

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