Evolutionary patterns of the mitochondrial genome in Metazoa: Exploring the role of mutation and selection in mitochondrial protein-coding genes

S. Castellana, S. Vicario, C. Saccone

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82 Citations (Scopus)

Abstract

The mitochondrial genome is a fundamental component of the eukaryotic domain of life, encoding for several important subunits of the respiratory chain, the main energy production system in cells. The processes by means of which mitochondrial DNA (mtDNA) replicates, expresses itself and evolves have been explored over the years, although various aspects are still debated. In this review, we present several key points in modern research on the role of evolutionary forces in affecting mitochondrial genomes in Metazoa. In particular, we assemble the main data on their evolution, describing the contributions of mutational pressure, purifying, and adaptive selection, and how they are related. We also provide data on the evolutionary fate of the mitochondrial synonymous variation, related to the nonsynonymous variation, in comparison with the pattern detected in the nucleus. Elevated mutational pressure characterizes the evolution of the mitochondrial synonymous variation, whereas purging selection, physiologically due to phenomena such as cell atresia and intracellular mtDNA selection, guarantees coding sequence functionality. This enables mitochondrial adaptive mutations to emerge and fix in the population, promoting mitonuclear coevolution.

Original languageEnglish
Pages (from-to)1067-1079
Number of pages13
JournalGenome Biology and Evolution
Volume3
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Animalia
Mitochondrial Genome
Mitochondrial Proteins
Mitochondrial DNA
mutation
mitochondrial DNA
genome
Pressure
Mutation
protein
gene
abnormal development
electron transport chain
Electron Transport
coevolution
Genes
production technology
genes
proteins
cells

Keywords

  • Genetic bottleneck
  • Mitochondria
  • Mutational pressure
  • Nuclear-mitochondrial coevolution
  • Selection
  • Synonymous codon usage

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

Cite this

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