TY - JOUR
T1 - Evolving beta-lactamase epidemiology in Enterobacteriaceae from Italian nationwide surveillance, October 2013
T2 - KPC-carbapenemase spreading among outpatients
AU - Giani, T.
AU - Antonelli, A.
AU - Caltagirone, M.
AU - Mauri, C.
AU - Nicchi, J.
AU - Arena, F.
AU - Nucleo, E.
AU - Bracco, S.
AU - Pantosti, A.
AU - Vismara, C.
AU - Pini, B.
AU - Andreoni, S.
AU - Dusi, P. A.
AU - Aschbacher, R.
AU - Scarparo, C.
AU - Sarti, M.
AU - Venturelli, C.
AU - Pecile, P.
AU - Manso, E.
AU - Spanu, T.
AU - Labonia, M.
AU - Buonopane, G.
AU - Giraldi, C.
AU - Luzzaro, F.
AU - Pagani, L.
AU - Rossolini, Gian Maria
AU - The AMCLI-CoSA survey participants
PY - 2017/8/3
Y1 - 2017/8/3
N2 - Extended-spectrum beta-lactamases (ESBLs), AmpCtype beta-lactamases (ACBLs) and carbapenemases are among the most important resistance mechanisms in Enterobacteriaceae. This study investigated the presence of these resistance mechanisms in consecutive non-replicate isolates of Escherichia coli (n = 2,352), Klebsiella pneumoniae (n = 697), and Proteus mirabilis (n = 275) from an Italian nationwide cross-sectional survey carried out in October 2013. Overall, 15.3% of isolates were non-susceptible to extended-spectrum cephalosporins but susceptible to carbapenems (ESCR-carbaS), while 4.3% were also non-susceptible to carbapenems (ESCR-carbaR). ESCR-carbaS isolates were contributed by all three species, with higher proportions among isolates from inpatients (20.3%) but remarkable proportions also among those from outpatients (11.1%). Most ESCRcarbaS isolates were ESBL-positive (90.5%), and most of them were contributed by E. coli carrying blaCTX-M group 1 genes. Acquired ACBLs were less common and mostly detected in P. mirabilis. ESCR-carbaR isolates were mostly contributed by K. pneumoniae (25.1% and 7.7% among K. pneumoniae isolates from inpatients and outpatients, respectively), with blaKPC as the most common carbapenemase gene. Results showed an increasing trend for both ESBL and carbapenemase producers in comparison with previous Italian surveys, also among outpatients.
AB - Extended-spectrum beta-lactamases (ESBLs), AmpCtype beta-lactamases (ACBLs) and carbapenemases are among the most important resistance mechanisms in Enterobacteriaceae. This study investigated the presence of these resistance mechanisms in consecutive non-replicate isolates of Escherichia coli (n = 2,352), Klebsiella pneumoniae (n = 697), and Proteus mirabilis (n = 275) from an Italian nationwide cross-sectional survey carried out in October 2013. Overall, 15.3% of isolates were non-susceptible to extended-spectrum cephalosporins but susceptible to carbapenems (ESCR-carbaS), while 4.3% were also non-susceptible to carbapenems (ESCR-carbaR). ESCR-carbaS isolates were contributed by all three species, with higher proportions among isolates from inpatients (20.3%) but remarkable proportions also among those from outpatients (11.1%). Most ESCRcarbaS isolates were ESBL-positive (90.5%), and most of them were contributed by E. coli carrying blaCTX-M group 1 genes. Acquired ACBLs were less common and mostly detected in P. mirabilis. ESCR-carbaR isolates were mostly contributed by K. pneumoniae (25.1% and 7.7% among K. pneumoniae isolates from inpatients and outpatients, respectively), with blaKPC as the most common carbapenemase gene. Results showed an increasing trend for both ESBL and carbapenemase producers in comparison with previous Italian surveys, also among outpatients.
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U2 - 10.2807/1560-7917.ES.2017.22.31.30583
DO - 10.2807/1560-7917.ES.2017.22.31.30583
M3 - Article
AN - SCOPUS:85028338752
VL - 22
JO - Eurosurveillance
JF - Eurosurveillance
SN - 1560-7917
IS - 31
ER -