Abstract
The clinical use of cells for the treatment of liver disease is not a mere hypothesis. Indeed, it has been known for more than 30 years that, following intraportal infusion, exogenous hepatocytes isolated from a donor liver engraft into the recipient hepatic parenchyma and express metabolic activity. These experimental results encouraged pilot clinical trials using hepatocytes transplantation to treat a variety of liver diseases. More recently, the discovery of liver stem/progenitor cells further fueled the interest in the field. However, it appears that successful liver cell therapy will require better understanding of the mechanisms governing liver regeneration and of their implication in cell transplantation. This review summarizes some recent advances in the field in a bench-to-bedside perspective.
| Original language | English |
|---|---|
| Pages (from-to) | 180-187 |
| Number of pages | 8 |
| Journal | Digestive and Liver Disease |
| Volume | 43 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
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Keywords
- Liver cell therapy
- Liver stem cells
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Evolving concepts in cell therapy of liver disease and current clinical perspectives. / Muraca, Maurizio.
In: Digestive and Liver Disease, Vol. 43, No. 3, 03.2011, p. 180-187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evolving concepts in cell therapy of liver disease and current clinical perspectives
AU - Muraca, Maurizio
PY - 2011/3
Y1 - 2011/3
N2 - The clinical use of cells for the treatment of liver disease is not a mere hypothesis. Indeed, it has been known for more than 30 years that, following intraportal infusion, exogenous hepatocytes isolated from a donor liver engraft into the recipient hepatic parenchyma and express metabolic activity. These experimental results encouraged pilot clinical trials using hepatocytes transplantation to treat a variety of liver diseases. More recently, the discovery of liver stem/progenitor cells further fueled the interest in the field. However, it appears that successful liver cell therapy will require better understanding of the mechanisms governing liver regeneration and of their implication in cell transplantation. This review summarizes some recent advances in the field in a bench-to-bedside perspective.
AB - The clinical use of cells for the treatment of liver disease is not a mere hypothesis. Indeed, it has been known for more than 30 years that, following intraportal infusion, exogenous hepatocytes isolated from a donor liver engraft into the recipient hepatic parenchyma and express metabolic activity. These experimental results encouraged pilot clinical trials using hepatocytes transplantation to treat a variety of liver diseases. More recently, the discovery of liver stem/progenitor cells further fueled the interest in the field. However, it appears that successful liver cell therapy will require better understanding of the mechanisms governing liver regeneration and of their implication in cell transplantation. This review summarizes some recent advances in the field in a bench-to-bedside perspective.
KW - Liver cell therapy
KW - Liver stem cells
UR - http://www.scopus.com/inward/record.url?scp=79551482651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551482651&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2010.08.007
DO - 10.1016/j.dld.2010.08.007
M3 - Article
C2 - 20869923
AN - SCOPUS:79551482651
VL - 43
SP - 180
EP - 187
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 3
ER -