Evolving pituitary hormone deficiency is associated with pituitary vasculopathy

Dynamic MR study in children with hypopituitarism, diabetes insipidus, and Langerhans cell histiocytosis

Mohamad Maghnie, Eugenio Genovese, Maurizio Aricò, Andrea Villa, Giampiero Beluffi, Rodolfo Campani, Francesca Seven

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

PURPOSE: To assess pituitary vascularization in children with hypopituitarism, central diabetes insipidus (DI), or Langerhans cell histiocytosis. MATERIALS AND METHODS: Dynamic MR images were obtained through the pituitary stalk after injection of gadopentetate dimeglumine in 21 patients (11 boys and 10 girls, aged 4-17 years) and 10 age-matched control subjects. RESULTS: Initial enhancement of the posterior pituitary lobe occurred simultaneously with that of the straight sinus in all subjects except four patients with central DI and a thick stalk. Enhancement of the entire anterior pituitary lobe was statistically significantly prolonged (P <.005) in the four patients with delayed initial posterior pituitary lobe enhancement. CONCLUSION: Fast-framing dynamic MR imaging provides new information on the blood supply of the hypothalamic pituitary area in normal and abnormal pituitary glands. Enhancement times exceeding 20 seconds for the posterior pituitary lobe and 30 seconds for the anterior pituitary lobe may suggest abnormal vascularization in the hypophyseal arteries and portal system.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalRadiology
Volume193
Issue number2
Publication statusPublished - Nov 1994

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Posterior Pituitary Gland
Hypopituitarism
Langerhans Cell Histiocytosis
Diabetes Insipidus
Pituitary Hormones
Neurogenic Diabetes Insipidus
Anterior Pituitary Gland
Pituitary Gland
Portal System
Gadolinium DTPA
Arteries
Injections

Keywords

  • Children, endocrine glands
  • Hormones
  • Magnetic resonance (MR), contrast enhancement
  • Magnetic resonance (MR), rapid imaging
  • Pituitary, diseases
  • Pituitary, hypopituitarism

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Evolving pituitary hormone deficiency is associated with pituitary vasculopathy : Dynamic MR study in children with hypopituitarism, diabetes insipidus, and Langerhans cell histiocytosis. / Maghnie, Mohamad; Genovese, Eugenio; Aricò, Maurizio; Villa, Andrea; Beluffi, Giampiero; Campani, Rodolfo; Seven, Francesca.

In: Radiology, Vol. 193, No. 2, 11.1994, p. 493-499.

Research output: Contribution to journalArticle

Maghnie, Mohamad ; Genovese, Eugenio ; Aricò, Maurizio ; Villa, Andrea ; Beluffi, Giampiero ; Campani, Rodolfo ; Seven, Francesca. / Evolving pituitary hormone deficiency is associated with pituitary vasculopathy : Dynamic MR study in children with hypopituitarism, diabetes insipidus, and Langerhans cell histiocytosis. In: Radiology. 1994 ; Vol. 193, No. 2. pp. 493-499.
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AB - PURPOSE: To assess pituitary vascularization in children with hypopituitarism, central diabetes insipidus (DI), or Langerhans cell histiocytosis. MATERIALS AND METHODS: Dynamic MR images were obtained through the pituitary stalk after injection of gadopentetate dimeglumine in 21 patients (11 boys and 10 girls, aged 4-17 years) and 10 age-matched control subjects. RESULTS: Initial enhancement of the posterior pituitary lobe occurred simultaneously with that of the straight sinus in all subjects except four patients with central DI and a thick stalk. Enhancement of the entire anterior pituitary lobe was statistically significantly prolonged (P <.005) in the four patients with delayed initial posterior pituitary lobe enhancement. CONCLUSION: Fast-framing dynamic MR imaging provides new information on the blood supply of the hypothalamic pituitary area in normal and abnormal pituitary glands. Enhancement times exceeding 20 seconds for the posterior pituitary lobe and 30 seconds for the anterior pituitary lobe may suggest abnormal vascularization in the hypophyseal arteries and portal system.

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