Abstract
PURPOSE: To assess pituitary vascularization in children with hypopituitarism, central diabetes insipidus (DI), or Langerhans cell histiocytosis. MATERIALS AND METHODS: Dynamic MR images were obtained through the pituitary stalk after injection of gadopentetate dimeglumine in 21 patients (11 boys and 10 girls, aged 4-17 years) and 10 age-matched control subjects. RESULTS: Initial enhancement of the posterior pituitary lobe occurred simultaneously with that of the straight sinus in all subjects except four patients with central DI and a thick stalk. Enhancement of the entire anterior pituitary lobe was statistically significantly prolonged (P <.005) in the four patients with delayed initial posterior pituitary lobe enhancement. CONCLUSION: Fast-framing dynamic MR imaging provides new information on the blood supply of the hypothalamic pituitary area in normal and abnormal pituitary glands. Enhancement times exceeding 20 seconds for the posterior pituitary lobe and 30 seconds for the anterior pituitary lobe may suggest abnormal vascularization in the hypophyseal arteries and portal system.
| Original language | English |
|---|---|
| Pages (from-to) | 493-499 |
| Number of pages | 7 |
| Journal | Radiology |
| Volume | 193 |
| Issue number | 2 |
| Publication status | Published - Nov 1994 |
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Keywords
- Children, endocrine glands
- Hormones
- Magnetic resonance (MR), contrast enhancement
- Magnetic resonance (MR), rapid imaging
- Pituitary, diseases
- Pituitary, hypopituitarism
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Evolving pituitary hormone deficiency is associated with pituitary vasculopathy : Dynamic MR study in children with hypopituitarism, diabetes insipidus, and Langerhans cell histiocytosis. / Maghnie, Mohamad; Genovese, Eugenio; Aricò, Maurizio; Villa, Andrea; Beluffi, Giampiero; Campani, Rodolfo; Seven, Francesca.
In: Radiology, Vol. 193, No. 2, 11.1994, p. 493-499.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evolving pituitary hormone deficiency is associated with pituitary vasculopathy
T2 - Dynamic MR study in children with hypopituitarism, diabetes insipidus, and Langerhans cell histiocytosis
AU - Maghnie, Mohamad
AU - Genovese, Eugenio
AU - Aricò, Maurizio
AU - Villa, Andrea
AU - Beluffi, Giampiero
AU - Campani, Rodolfo
AU - Seven, Francesca
PY - 1994/11
Y1 - 1994/11
N2 - PURPOSE: To assess pituitary vascularization in children with hypopituitarism, central diabetes insipidus (DI), or Langerhans cell histiocytosis. MATERIALS AND METHODS: Dynamic MR images were obtained through the pituitary stalk after injection of gadopentetate dimeglumine in 21 patients (11 boys and 10 girls, aged 4-17 years) and 10 age-matched control subjects. RESULTS: Initial enhancement of the posterior pituitary lobe occurred simultaneously with that of the straight sinus in all subjects except four patients with central DI and a thick stalk. Enhancement of the entire anterior pituitary lobe was statistically significantly prolonged (P <.005) in the four patients with delayed initial posterior pituitary lobe enhancement. CONCLUSION: Fast-framing dynamic MR imaging provides new information on the blood supply of the hypothalamic pituitary area in normal and abnormal pituitary glands. Enhancement times exceeding 20 seconds for the posterior pituitary lobe and 30 seconds for the anterior pituitary lobe may suggest abnormal vascularization in the hypophyseal arteries and portal system.
AB - PURPOSE: To assess pituitary vascularization in children with hypopituitarism, central diabetes insipidus (DI), or Langerhans cell histiocytosis. MATERIALS AND METHODS: Dynamic MR images were obtained through the pituitary stalk after injection of gadopentetate dimeglumine in 21 patients (11 boys and 10 girls, aged 4-17 years) and 10 age-matched control subjects. RESULTS: Initial enhancement of the posterior pituitary lobe occurred simultaneously with that of the straight sinus in all subjects except four patients with central DI and a thick stalk. Enhancement of the entire anterior pituitary lobe was statistically significantly prolonged (P <.005) in the four patients with delayed initial posterior pituitary lobe enhancement. CONCLUSION: Fast-framing dynamic MR imaging provides new information on the blood supply of the hypothalamic pituitary area in normal and abnormal pituitary glands. Enhancement times exceeding 20 seconds for the posterior pituitary lobe and 30 seconds for the anterior pituitary lobe may suggest abnormal vascularization in the hypophyseal arteries and portal system.
KW - Children, endocrine glands
KW - Hormones
KW - Magnetic resonance (MR), contrast enhancement
KW - Magnetic resonance (MR), rapid imaging
KW - Pituitary, diseases
KW - Pituitary, hypopituitarism
UR - http://www.scopus.com/inward/record.url?scp=0028143440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028143440&partnerID=8YFLogxK
M3 - Article
C2 - 7972767
AN - SCOPUS:0028143440
VL - 193
SP - 493
EP - 499
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -