Evolving role of myeloablative chemotherapy in the treatment of childhood brain tumours

Sandro Dallorso, G. Dini, R. Ladenstein, A. Cama, C. Milanaccio, S. Barra, B. Cappelli, M. L. Garrè

Research output: Contribution to journalArticle

Abstract

Primary brain tumours, a heterogeneous group of cancer that constitute the second most common cancer in childhood, were historically treated with neurosurgical resection and radiation therapy. Chemotherapy has proven to be beneficial for some histological types, which has since led to exploration of the role of high-dose chemotherapy and haematopoietic stem cell rescue. Patients with high-grade glial tumours, primitive neuroectodermal tumours and high-risk medulloblastoma usually fare poorly. The indicators of bad prognosis are metastatic status, extent of resection and age. Children

Original languageEnglish
JournalBone Marrow Transplantation
Volume35
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Mar 2005

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Keywords

  • Autologous stem cell transplantation
  • Brain tumours
  • Childhood

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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