TY - JOUR
T1 - Evolving role of myeloablative chemotherapy in the treatment of childhood brain tumours
AU - Dallorso, Sandro
AU - Dini, G.
AU - Ladenstein, R.
AU - Cama, A.
AU - Milanaccio, C.
AU - Barra, S.
AU - Cappelli, B.
AU - Garrè, M. L.
PY - 2005/3
Y1 - 2005/3
N2 - Primary brain tumours, a heterogeneous group of cancer that constitute the second most common cancer in childhood, were historically treated with neurosurgical resection and radiation therapy. Chemotherapy has proven to be beneficial for some histological types, which has since led to exploration of the role of high-dose chemotherapy and haematopoietic stem cell rescue. Patients with high-grade glial tumours, primitive neuroectodermal tumours and high-risk medulloblastoma usually fare poorly. The indicators of bad prognosis are metastatic status, extent of resection and age. Children
AB - Primary brain tumours, a heterogeneous group of cancer that constitute the second most common cancer in childhood, were historically treated with neurosurgical resection and radiation therapy. Chemotherapy has proven to be beneficial for some histological types, which has since led to exploration of the role of high-dose chemotherapy and haematopoietic stem cell rescue. Patients with high-grade glial tumours, primitive neuroectodermal tumours and high-risk medulloblastoma usually fare poorly. The indicators of bad prognosis are metastatic status, extent of resection and age. Children
KW - Autologous stem cell transplantation
KW - Brain tumours
KW - Childhood
UR - http://www.scopus.com/inward/record.url?scp=18144430659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18144430659&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1704841
DO - 10.1038/sj.bmt.1704841
M3 - Article
C2 - 15812527
AN - SCOPUS:18144430659
VL - 35
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - SUPPL. 1
ER -